# Diffusion Model-Based Data Augmentation for Enhanced Neuron Segmentation

arXiv: https://arxiv.org/abs/2601.15779 · HTML: https://mlsanity.com/paper/2601.15779/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Medical imaging and segmentation, one of 14 directions in Diffusion models.
- Builds on 8 of its 20 references that are in the map.
- First posted on arXiv 22 Jan 2026.

## Placed in

- Diffusion models / [Medical imaging and segmentation](https://mlsanity.com/diffusion/medical-imaging-and-segmentation/)

## Builds on (most cited first, 8 of 8)

- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [Mamba: Linear-Time Sequence Modeling with Selective State Spaces](https://mlsanity.com/paper/2312.00752/) (2023)
- [Image-to-Image Translation with Conditional Adversarial Networks](https://mlsanity.com/paper/1611.07004/) (2016)
- [Swin UNETR: Swin Transformers for Semantic Segmentation of Brain Tumors in MRI Images](https://mlsanity.com/paper/2201.01266/) (2022)
- [SegMamba: Long-range Sequential Modeling Mamba For 3D Medical Image Segmentation](https://mlsanity.com/paper/2401.13560/) (2024)
- [Superhuman Accuracy on the SNEMI3D Connectomics Challenge](https://mlsanity.com/paper/1706.00120/) (2017)
- [Red blood cell image generation for data augmentation using Conditional Generative Adversarial Networks](https://mlsanity.com/paper/1901.06219/) (2019)

## Abstract (arXiv)

Neuron segmentation in electron microscopy (EM) aims to reconstruct the complete neuronal connectome; however, current deep learning-based methods are limited by their reliance on large-scale training data and extensive, time-consuming manual annotations. Traditional methods augment the training set through geometric and photometric transformations; however, the generated samples remain highly correlated with the original images and lack structural diversity. To address this limitation, we propose a diffusion-based data augmentation framework capable of generating diverse and structurally plausible image-label pairs for neuron segmentation. Specifically, the framework employs a resolution-aware conditional diffusion model with multi-scale conditioning and EM resolution priors to enable voxel-level image synthesis from 3D masks. It further incorporates a biology-guided mask remodeling module that produces augmented masks with enhanced structural realism. Together, these components effectively enrich the training set and improve segmentation performance. On the AC3 and AC4 datasets under low-annotation regimes, our method improves the ARAND metric by 32.1% and 30.7%, respectively, when combined with two different post-processing methods. Our code is available at https://github.com/HeadLiuYun/NeuroDiff.