# AgentEHR: Advancing Autonomous Clinical Decision-Making via Retrospective Summarization

arXiv: https://arxiv.org/abs/2601.13918 · HTML: https://mlsanity.com/paper/2601.13918/

## Key facts

- Cited by 4 papers in the map (data through 14 Oct 2026).
- Builds on 16 of its 35 references that are in the map.
- First posted on arXiv 20 Jan 2026.

## Builds on (most cited first, 16 of 16)

- [ReAct: Synergizing Reasoning and Acting in Language Models](https://mlsanity.com/paper/2210.03629/) (2022)
- [Large Language Models Encode Clinical Knowledge](https://mlsanity.com/paper/2212.13138/) (2022)
- [Capabilities of GPT-4 on Medical Challenge Problems](https://mlsanity.com/paper/2303.13375/) (2023)
- [Benchmarking Retrieval-Augmented Generation for Medicine](https://mlsanity.com/paper/2402.13178/) (2024)
- [MEM1: Learning to Synergize Memory and Reasoning for Efficient Long-Horizon Agents](https://mlsanity.com/paper/2506.15841/) (2025)
- [ReSum: Unlocking Long-Horizon Search Intelligence via Context Summarization](https://mlsanity.com/paper/2509.13313/) (2025)
- [MiroThinker: Pushing the Performance Boundaries of Open-Source Research Agents via Model, Context, and Interactive Scaling](https://mlsanity.com/paper/2511.11793/) (2025)
- [Text-to-SQL Generation for Question Answering on Electronic Medical Records](https://mlsanity.com/paper/1908.01839/) (2019)
- [Automatic Interactive Evaluation for Large Language Models with State Aware Patient Simulator](https://mlsanity.com/paper/2403.08495/) (2024)
- [TIMER: Temporal Instruction Modeling and Evaluation for Longitudinal Clinical Records](https://mlsanity.com/paper/2503.04176/) (2025)
- [MedBrowseComp: Benchmarking Medical Deep Research and Computer Use](https://mlsanity.com/paper/2505.14963/) (2025)
- [Large Language Models are Powerful Electronic Health Record Encoders](https://mlsanity.com/paper/2502.17403/) (2025)
- [Intelligent Clinical Documentation: Harnessing Generative AI for Patient-Centric Clinical Note Generation](https://mlsanity.com/paper/2405.18346/) (2024)
- [ReflecTool: Towards Reflection-Aware Tool-Augmented Clinical Agents](https://mlsanity.com/paper/2410.17657/) (2024)
- [Enhancing Clinical Efficiency through LLM: Discharge Note Generation for Cardiac Patients](https://mlsanity.com/paper/2404.05144/) (2024)
- [EHR-MCP: Real-world Evaluation of Clinical Information Retrieval by Large Language Models via Model Context Protocol](https://mlsanity.com/paper/2509.15957/) (2025)

## Built on by (most cited first, 4 of 4)

- [PhysicianBench: Evaluating LLM Agents in Real-World EHR Environments](https://mlsanity.com/paper/2605.02240/) (2026)
- [ClinSeekAgent: Automating Multimodal Evidence Seeking for Agentic Clinical Reasoning](https://mlsanity.com/paper/2605.20176/) (2026)
- [AutoMedBench: Towards Medical AutoResearch with Agentic AI Models](https://mlsanity.com/paper/2606.01961/) (2026)
- [CodeClinic: Evaluating Automation of Coding Skills for Clinical Reasoning Agents](https://mlsanity.com/paper/2605.09675/) (2026)

## Abstract (arXiv)

Large Language Models have demonstrated profound utility in the medical domain. However, their application to autonomous Electronic Health Records~(EHRs) navigation remains constrained by a reliance on curated inputs and simplified retrieval tasks. To bridge the gap between idealized experimental settings and realistic clinical environments, we present AgentEHR. This benchmark challenges agents to execute complex decision-making tasks, such as diagnosis and treatment planning, requiring long-range interactive reasoning directly within raw and high-noise databases. In tackling these tasks, we identify that existing summarization methods inevitably suffer from critical information loss and fractured reasoning continuity. To address this, we propose RetroSum, a novel framework that unifies a retrospective summarization mechanism with an evolving experience strategy. By dynamically re-evaluating interaction history, the retrospective mechanism prevents long-context information loss and ensures unbroken logical coherence. Additionally, the evolving strategy bridges the domain gap by retrieving accumulated experience from a memory bank. Extensive empirical evaluations demonstrate that RetroSum achieves performance gains of up to 29.16% over competitive baselines, while significantly decreasing total interaction errors by up to 92.3%.