# Dr. Assistant: Enhancing Clinical Diagnostic Inquiry via Structured Diagnostic Reasoning Data and Reinforcement Learning

arXiv: https://arxiv.org/abs/2601.13690 · HTML: https://mlsanity.com/paper/2601.13690/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Clinical and biomedical applications, one of 17 directions in LLM reasoning.
- Builds on 14 of its 42 references that are in the map.
- First posted on arXiv 20 Jan 2026.

## Placed in

- LLM reasoning / [Clinical and biomedical applications](https://mlsanity.com/lr/clinical-and-biomedical-applications/)

## Builds on (most cited first, 14 of 14)

- [Qwen3 Technical Report](https://mlsanity.com/paper/2505.09388/) (2025)
- [DeepSeek-R1: Incentivizing Reasoning Capability in LLMs via Reinforcement Learning](https://mlsanity.com/paper/2501.12948/) (2025)
- [DAPO: An Open-Source LLM Reinforcement Learning System at Scale](https://mlsanity.com/paper/2503.14476/) (2025)
- [HybridFlow: A Flexible and Efficient RLHF Framework](https://mlsanity.com/paper/2409.19256/) (2024)
- [HealthBench: Evaluating Large Language Models Towards Improved Human Health](https://mlsanity.com/paper/2505.08775/) (2025)
- [HuatuoGPT-o1, Towards Medical Complex Reasoning with LLMs](https://mlsanity.com/paper/2412.18925/) (2024)
- [HuatuoGPT, towards Taming Language Model to Be a Doctor](https://mlsanity.com/paper/2305.15075/) (2023)
- [Large Language Models for Education: A Survey and Outlook](https://mlsanity.com/paper/2403.18105/) (2024)
- [Med42-v2: A Suite of Clinical LLMs](https://mlsanity.com/paper/2408.06142/) (2024)
- [Baichuan-M2: Scaling Medical Capability with Large Verifier System](https://mlsanity.com/paper/2509.02208/) (2025)
- [Reinforcement Fine-Tuning Naturally Mitigates Forgetting in Continual Post-Training](https://mlsanity.com/paper/2507.05386/) (2025)
- [Doctor-R1: Mastering Clinical Inquiry with Experiential Agentic Reinforcement Learning](https://mlsanity.com/paper/2510.04284/) (2025)
- [The Dialogue That Heals: A Comprehensive Evaluation of Doctor Agents' Inquiry Capability](https://mlsanity.com/paper/2509.24958/) (2025)
- [GAPS: A Clinically Grounded, Automated Benchmark for Evaluating AI Clinicians](https://mlsanity.com/paper/2510.13734/) (2025)

## Abstract (arXiv)

Clinical Decision Support Systems (CDSSs) provide reasoning and inquiry guidance for physicians, yet they face notable challenges, including high maintenance costs and low generalization capability. Recently, Large Language Models (LLMs) have been widely adopted in healthcare due to their extensive knowledge reserves, retrieval, and communication capabilities. While LLMs show promise and excel at medical benchmarks, their diagnostic reasoning and inquiry skills are constrained. To mitigate this issue, we propose (1) Clinical Diagnostic Reasoning Data (CDRD) structure to capture abstract clinical reasoning logic, and a pipeline for its construction, and (2) the Dr. Assistant, a clinical diagnostic model equipped with clinical reasoning and inquiry skills. Its training involves a two-stage process: SFT, followed by RL with a tailored reward function. We also introduce a benchmark to evaluate both diagnostic reasoning and inquiry. Our experiments demonstrate that the Dr. Assistant outperforms open-source models and achieves competitive performance to closed-source models, providing an effective solution for clinical diagnostic inquiry guidance. Project information can be found at: https://github.com/YGswu/Dr.-Assistant .