# Neural Organ Transplantation (NOT): Checkpoint-Based Modular Adaptation for Transformer Models

arXiv: https://arxiv.org/abs/2601.13580 · HTML: https://mlsanity.com/paper/2601.13580/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 23 of its 33 references that are in the map.
- First posted on arXiv 20 Jan 2026.

## Builds on (most cited first, 23 of 23)

- [PyTorch: An Imperative Style, High-Performance Deep Learning Library](https://mlsanity.com/paper/1912.01703/) (2019)
- [LoRA: Low-Rank Adaptation of Large Language Models](https://mlsanity.com/paper/2106.09685/) (2021)
- [Distilling the Knowledge in a Neural Network](https://mlsanity.com/paper/1503.02531/) (2015)
- [Parameter-Efficient Transfer Learning for NLP](https://mlsanity.com/paper/1902.00751/) (2019)
- [Prefix-Tuning: Optimizing Continuous Prompts for Generation](https://mlsanity.com/paper/2101.00190/) (2021)
- [The Power of Scale for Parameter-Efficient Prompt Tuning](https://mlsanity.com/paper/2104.08691/) (2021)
- [QLoRA: Efficient Finetuning of Quantized LLMs](https://mlsanity.com/paper/2305.14314/) (2023)
- [Pointer Sentinel Mixture Models](https://mlsanity.com/paper/1609.07843/) (2016)
- [Model soups: averaging weights of multiple fine-tuned models improves accuracy without increasing inference time](https://mlsanity.com/paper/2203.05482/) (2022)
- [Editing Models with Task Arithmetic](https://mlsanity.com/paper/2212.04089/) (2022)
- [BERT Rediscovers the Classical NLP Pipeline](https://mlsanity.com/paper/1905.05950/) (2019)
- [Few-Shot Parameter-Efficient Fine-Tuning is Better and Cheaper than In-Context Learning](https://mlsanity.com/paper/2205.05638/) (2022)
- [TIES-Merging: Resolving Interference When Merging Models](https://mlsanity.com/paper/2306.01708/) (2023)
- [A Primer in BERTology: What we know about how BERT works](https://mlsanity.com/paper/2002.12327/) (2020)
- [AdapterFusion: Non-Destructive Task Composition for Transfer Learning](https://mlsanity.com/paper/2005.00247/) (2020)
- [DoRA: Weight-Decomposed Low-Rank Adaptation](https://mlsanity.com/paper/2402.09353/) (2024)
- [AdaLoRA: Adaptive Budget Allocation for Parameter-Efficient Fine-Tuning](https://mlsanity.com/paper/2303.10512/) (2023)
- [MedAlpaca -- An Open-Source Collection of Medical Conversational AI Models and Training Data](https://mlsanity.com/paper/2304.08247/) (2023)
- [Understanding image representations by measuring their equivariance and equivalence](https://mlsanity.com/paper/1411.5908/) (2014)
- [Convergent Learning: Do different neural networks learn the same representations?](https://mlsanity.com/paper/1511.07543/) (2015)
- [Revisiting Model Stitching to Compare Neural Representations](https://mlsanity.com/paper/2106.07682/) (2021)
- [Composing Parameter-Efficient Modules with Arithmetic Operations](https://mlsanity.com/paper/2306.14870/) (2023)
- [Similarity and Matching of Neural Network Representations](https://mlsanity.com/paper/2110.14633/) (2021)

## Abstract (arXiv)

We introduce Neural Organ Transplantation (NOT), a modular adaptation framework that enables trained transformer layers to function as reusable transferable checkpoints for domain adaptation. Unlike conventional fine-tuning approaches that tightly couple trained parameters to specific model instances and training data, NOT extracts contiguous layer subsets ("donor organs") from pre-trained models, trains them independently on domain-specific data, and saves them as standalone checkpoint files that can be transplanted into compatible recipient models without access to the original training data. Through experiments on three decoder-only transformer architectures spanning 124M to 20B parameters (GPT-2, TinyLlama, and GPT-OSS), we demonstrate that donor transplantation substantially outperforms existing adaptation methods, achieving an order-of-magnitude improvement in perplexity over LoRA while training significantly faster. The method exhibits position dependence, with early insertion positions yielding optimal results. Cross-domain transfer at billion-parameter scale reveals unexpected regularization benefits. These findings demonstrate that transformer middle layers can support efficient modular transfer for decoder-only architectures, enabling privacy-preserving expertise sharing through checkpoint distribution. We note that this approach is currently limited to decoder-only models; preliminary experiments on encoder-based architectures show reduced effectiveness.