# SSPFormer: Self-Supervised Pretrained Transformer for MRI Images

arXiv: https://arxiv.org/abs/2601.12747 · HTML: https://mlsanity.com/paper/2601.12747/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 40 of its 49 references that are in the map.
- First posted on arXiv 19 Jan 2026.

## Builds on (most cited first, 30 of 40)

- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [Masked Autoencoders Are Scalable Vision Learners](https://mlsanity.com/paper/2111.06377/) (2021)
- [Batch Normalization: Accelerating Deep Network Training by Reducing Internal Covariate Shift](https://mlsanity.com/paper/1502.03167/) (2015)
- [Layer Normalization](https://mlsanity.com/paper/1607.06450/) (2016)
- [Advances and Open Problems in Federated Learning](https://mlsanity.com/paper/1912.04977/) (2019)
- [BEiT: BERT Pre-Training of Image Transformers](https://mlsanity.com/paper/2106.08254/) (2021)
- [V-Net: Fully Convolutional Neural Networks for Volumetric Medical Image Segmentation](https://mlsanity.com/paper/1606.04797/) (2016)
- [Learning both Weights and Connections for Efficient Neural Networks](https://mlsanity.com/paper/1506.02626/) (2015)
- [SwinIR: Image Restoration Using Swin Transformer](https://mlsanity.com/paper/2108.10257/) (2021)
- [Restormer: Efficient Transformer for High-Resolution Image Restoration](https://mlsanity.com/paper/2111.09881/) (2021)
- [TransUNet: Transformers Make Strong Encoders for Medical Image Segmentation](https://mlsanity.com/paper/2102.04306/) (2021)
- [Attention U-Net: Learning Where to Look for the Pancreas](https://mlsanity.com/paper/1804.03999/) (2018)
- [ESRGAN: Enhanced Super-Resolution Generative Adversarial Networks](https://mlsanity.com/paper/1809.00219/) (2018)
- [Image Super-Resolution Using Deep Convolutional Networks](https://mlsanity.com/paper/1501.00092/) (2014)
- [A Survey on Deep Learning in Medical Image Analysis](https://mlsanity.com/paper/1702.05747/) (2017)
- [SimMIM: A Simple Framework for Masked Image Modeling](https://mlsanity.com/paper/2111.09886/) (2021)
- [Pre-Trained Image Processing Transformer](https://mlsanity.com/paper/2012.00364/) (2020)
- [Self-supervised Visual Feature Learning with Deep Neural Networks: A Survey](https://mlsanity.com/paper/1902.06162/) (2019)
- [FFDNet: Toward a Fast and Flexible Solution for CNN based Image Denoising](https://mlsanity.com/paper/1710.04026/) (2017)
- [Making Convolutional Networks Shift-Invariant Again](https://mlsanity.com/paper/1904.11486/) (2019)
- [Frequency Principle: Fourier Analysis Sheds Light on Deep Neural Networks](https://mlsanity.com/paper/1901.06523/) (2019)
- [Learning a Variational Network for Reconstruction of Accelerated MRI Data](https://mlsanity.com/paper/1704.00447/) (2017)
- [Toward Convolutional Blind Denoising of Real Photographs](https://mlsanity.com/paper/1807.04686/) (2018)
- [Fast, Accurate, and Lightweight Super-Resolution with Cascading Residual Network](https://mlsanity.com/paper/1803.08664/) (2018)
- [VAE with a VampPrior](https://mlsanity.com/paper/1705.07120/) (2017)
- [Lightweight Image Super-Resolution with Information Multi-distillation Network](https://mlsanity.com/paper/1909.11856/) (2019)
- [ResUNet++: An Advanced Architecture for Medical Image Segmentation](https://mlsanity.com/paper/1911.07067/) (2019)
- [Models Genesis: Generic Autodidactic Models for 3D Medical Image Analysis](https://mlsanity.com/paper/1908.06912/) (2019)
- [MISSFormer: An Effective Medical Image Segmentation Transformer](https://mlsanity.com/paper/2109.07162/) (2021)

## Abstract (arXiv)

The pre-trained transformer demonstrates remarkable generalization ability in natural image processing. However, directly transferring it to magnetic resonance images faces two key challenges: the inability to adapt to the specificity of medical anatomical structures and the limitations brought about by the privacy and scarcity of medical data. To address these issues, this paper proposes a Self-Supervised Pretrained Transformer (SSPFormer) for MRI images, which effectively learns domain-specific feature representations of medical images by leveraging unlabeled raw imaging data. To tackle the domain gap and data scarcity, we introduce inverse frequency projection masking, which prioritizes the reconstruction of high-frequency anatomical regions to enforce structure-aware representation learning. Simultaneously, to enhance robustness against real-world MRI artifacts, we employ frequency-weighted FFT noise enhancement that injects physiologically realistic noise into the Fourier domain. Together, these strategies enable the model to learn domain-invariant and artifact-robust features directly from raw scans. Through extensive experiments on segmentation, super-resolution, and denoising tasks, the proposed SSPFormer achieves state-of-the-art performance, fully verifying its ability to capture fine-grained MRI image fidelity and adapt to clinical application requirements.