# Multi-Stage Patient Role-Playing Framework for Realistic Clinical Interactions

arXiv: https://arxiv.org/abs/2601.10951 · HTML: https://mlsanity.com/paper/2601.10951/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 15 of its 23 references that are in the map.
- First posted on arXiv 16 Jan 2026.

## Builds on (most cited first, 15 of 15)

- [The Llama 3 Herd of Models](https://mlsanity.com/paper/2407.21783/) (2024)
- [Gemini 1.5: Unlocking multimodal understanding across millions of tokens of context](https://mlsanity.com/paper/2403.05530/) (2024)
- [ChatGLM: A Family of Large Language Models from GLM-130B to GLM-4 All Tools](https://mlsanity.com/paper/2406.12793/) (2024)
- [Character-LLM: A Trainable Agent for Role-Playing](https://mlsanity.com/paper/2310.10158/) (2023)
- [Agent Hospital: A Simulacrum of Hospital with Evolvable Medical Agents](https://mlsanity.com/paper/2405.02957/) (2024)
- [From Persona to Personalization: A Survey on Role-Playing Language Agents](https://mlsanity.com/paper/2404.18231/) (2024)
- [CharacterEval: A Chinese Benchmark for Role-Playing Conversational Agent Evaluation](https://mlsanity.com/paper/2401.01275/) (2024)
- [AI Hospital: Benchmarking Large Language Models in a Multi-agent Medical Interaction Simulator](https://mlsanity.com/paper/2402.09742/) (2024)
- [MedRAG: Enhancing Retrieval-augmented Generation with Knowledge Graph-Elicited Reasoning for Healthcare Copilot](https://mlsanity.com/paper/2502.04413/) (2025)
- [Self-Evolving Multi-Agent Simulations for Realistic Clinical Interactions](https://mlsanity.com/paper/2503.22678/) (2025)
- [Automatic Interactive Evaluation for Large Language Models with State Aware Patient Simulator](https://mlsanity.com/paper/2403.08495/) (2024)
- [PatientSim: A Persona-Driven Simulator for Realistic Doctor-Patient Interactions](https://mlsanity.com/paper/2505.17818/) (2025)
- [LLMs Can Simulate Standardized Patients via Agent Coevolution](https://mlsanity.com/paper/2412.11716/) (2024)
- [Quantifying and Optimizing Global Faithfulness in Persona-driven Role-playing](https://mlsanity.com/paper/2405.07726/) (2024)
- [Enhancing Large Language Models for Clinical Decision Support by Incorporating Clinical Practice Guidelines](https://mlsanity.com/paper/2401.11120/) (2024)

## Built on by (most cited first, 1 of 1)

- [Patients With Personality: Realistic Patient Simulation through Controlled Diversity and Selective Disclosure](https://mlsanity.com/paper/2606.17441/) (2026)

## Abstract (arXiv)

The simulation of realistic clinical interactions plays a pivotal role in advancing clinical Large Language Models (LLMs) and supporting medical diagnostic education. Existing approaches and benchmarks rely on generic or LLM-generated dialogue data, which limits the authenticity and diversity of doctor-patient interactions. In this work, we propose the first Chinese patient simulation dataset (Ch-PatientSim), constructed from realistic clinical interaction scenarios to comprehensively evaluate the performance of models in emulating patient behavior. Patients are simulated based on a five-dimensional persona structure. To address issues of the persona class imbalance, a portion of the dataset is augmented using few-shot generation, followed by manual verification. We evaluate various state-of-the-art LLMs and find that most produce overly formal responses that lack individual personality. To address this limitation, we propose a training-free Multi-Stage Patient Role-Playing (MSPRP) framework, which decomposes interactions into three stages to ensure both personalization and realism in model responses. Experimental results demonstrate that our approach significantly improves model performance across multiple dimensions of patient simulation.