# DW-DGAT: Dynamically Weighted Dual Graph Attention Network for Neurodegenerative Disease Diagnosis

arXiv: https://arxiv.org/abs/2601.10001 · HTML: https://mlsanity.com/paper/2601.10001/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 11 of its 48 references that are in the map.
- First posted on arXiv 15 Jan 2026.

## Builds on (most cited first, 11 of 11)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Adam: A Method for Stochastic Optimization](https://mlsanity.com/paper/1412.6980/) (2014)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [Very Deep Convolutional Networks for Large-Scale Image Recognition](https://mlsanity.com/paper/1409.1556/) (2014)
- [Semi-Supervised Classification with Graph Convolutional Networks](https://mlsanity.com/paper/1609.02907/) (2016)
- [Generative Adversarial Networks](https://mlsanity.com/paper/2203.00667/) (2022)
- [Gaussian Error Linear Units (GELUs)](https://mlsanity.com/paper/1606.08415/) (2016)
- [Improved Training of Wasserstein GANs](https://mlsanity.com/paper/1704.00028/) (2017)
- [How Attentive are Graph Attention Networks?](https://mlsanity.com/paper/2105.14491/) (2021)
- [FBNETGEN: Task-aware GNN-based fMRI Analysis via Functional Brain Network Generation](https://mlsanity.com/paper/2205.12465/) (2022)
- [A Graph Gaussian Embedding Method for Predicting Alzheimer's Disease Progression with MEG Brain Networks](https://mlsanity.com/paper/2005.05784/) (2020)

## Abstract (arXiv)

Parkinson's disease (PD) and Alzheimer's disease (AD) are the two most prevalent and incurable neurodegenerative diseases (NDs) worldwide, for which early diagnosis is critical to delay their progression. However, the high dimensionality of multi-metric data with diverse structural forms, the heterogeneity of neuroimaging and phenotypic data, and class imbalance collectively pose significant challenges to early ND diagnosis. To address these challenges, we propose a dynamically weighted dual graph attention network (DW-DGAT) that integrates: (1) a general-purpose data fusion strategy to merge three structural forms of multi-metric data; (2) a dual graph attention architecture based on brain regions and inter-sample relationships to extract both micro- and macro-level features; and (3) a class weight generation mechanism combined with two stable and effective loss functions to mitigate class imbalance. Rigorous experiments, based on the Parkinson Progression Marker Initiative (PPMI) and Alzheimer's Disease Neuroimaging Initiative (ADNI) studies, demonstrate the state-of-the-art performance of our approach.