# Instance camera focus prediction for crystal agglomeration classification

arXiv: https://arxiv.org/abs/2601.09004 · HTML: https://mlsanity.com/paper/2601.09004/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 5 of its 14 references that are in the map.
- First posted on arXiv 13 Jan 2026.

## Builds on (most cited first, 5 of 5)

- [Microsoft COCO: Common Objects in Context](https://mlsanity.com/paper/1405.0312/) (2014)
- [Mask R-CNN](https://mlsanity.com/paper/1703.06870/) (2017)
- [Depth Anything V2](https://mlsanity.com/paper/2406.09414/) (2024)
- [YOLOv12: Attention-Centric Real-Time Object Detectors](https://mlsanity.com/paper/2502.12524/) (2025)
- [Efficient Microscopic Image Instance Segmentation for Food Crystal Quality Control](https://mlsanity.com/paper/2409.18291/) (2024)

## Abstract (arXiv)

Agglomeration refers to the process of crystal clustering due to interparticle forces. Crystal agglomeration analysis from microscopic images is challenging due to the inherent limitations of two-dimensional imaging. Overlapping crystals may appear connected even when located at different depth layers. Because optical microscopes have a shallow depth of field, crystals that are in-focus and out-of-focus in the same image typically reside on different depth layers and do not constitute true agglomeration. To address this, we first quantified camera focus with an instance camera focus prediction network to predict 2 class focus level that aligns better with visual observations than traditional image processing focus measures. Then an instance segmentation model is combined with the predicted focus level for agglomeration classification. Our proposed method has a higher agglomeration classification and segmentation accuracy than the baseline models on ammonium perchlorate crystal and sugar crystal dataset.