# Exploiting DINOv3-Based Self-Supervised Features for Robust Few-Shot Medical Image Segmentation

arXiv: https://arxiv.org/abs/2601.08078 · HTML: https://mlsanity.com/paper/2601.08078/

## Key facts

- Cited by 3 papers in the map (data through 14 Oct 2026).
- Builds on 31 of its 65 references that are in the map.
- First posted on arXiv 12 Jan 2026.

## Builds on (most cited first, 30 of 31)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [DINOv2: Learning Robust Visual Features without Supervision](https://mlsanity.com/paper/2304.07193/) (2023)
- [Masked Autoencoders Are Scalable Vision Learners](https://mlsanity.com/paper/2111.06377/) (2021)
- [Emerging Properties in Self-Supervised Vision Transformers](https://mlsanity.com/paper/2104.14294/) (2021)
- [Encoder-Decoder with Atrous Separable Convolution for Semantic Image Segmentation](https://mlsanity.com/paper/1802.02611/) (2018)
- [SegFormer: Simple and Efficient Design for Semantic Segmentation with Transformers](https://mlsanity.com/paper/2105.15203/) (2021)
- [Exploring Simple Siamese Representation Learning](https://mlsanity.com/paper/2011.10566/) (2020)
- [Pyramid Scene Parsing Network](https://mlsanity.com/paper/1612.01105/) (2016)
- [Improved Baselines with Momentum Contrastive Learning](https://mlsanity.com/paper/2003.04297/) (2020)
- [Improved Regularization of Convolutional Neural Networks with Cutout](https://mlsanity.com/paper/1708.04552/) (2017)
- [SegNet: A Deep Convolutional Encoder-Decoder Architecture for Image Segmentation](https://mlsanity.com/paper/1511.00561/) (2015)
- [DINOv3](https://mlsanity.com/paper/2508.10104/) (2025)
- [VideoMAE: Masked Autoencoders are Data-Efficient Learners for Self-Supervised Video Pre-Training](https://mlsanity.com/paper/2203.12602/) (2022)
- [Swin UNETR: Swin Transformers for Semantic Segmentation of Brain Tumors in MRI Images](https://mlsanity.com/paper/2201.01266/) (2022)
- [UNet++: Redesigning Skip Connections to Exploit Multiscale Features in Image Segmentation](https://mlsanity.com/paper/1912.05074/) (2019)
- [Segmentation Transformer: Object-Contextual Representations for Semantic Segmentation](https://mlsanity.com/paper/1909.11065/) (2019)
- [VideoMAE V2: Scaling Video Masked Autoencoders with Dual Masking](https://mlsanity.com/paper/2303.16727/) (2023)
- [Uncertainty-aware Self-ensembling Model for Semi-supervised 3D Left Atrium Segmentation](https://mlsanity.com/paper/1907.07034/) (2019)
- [3D MRI brain tumor segmentation using autoencoder regularization](https://mlsanity.com/paper/1810.11654/) (2018)
- [Attention Gated Networks: Learning to Leverage Salient Regions in Medical Images](https://mlsanity.com/paper/1808.08114/) (2018)
- [Localizing Objects with Self-Supervised Transformers and no Labels](https://mlsanity.com/paper/2109.14279/) (2021)
- [ResUNet++: An Advanced Architecture for Medical Image Segmentation](https://mlsanity.com/paper/1911.07067/) (2019)
- [MultiResUNet : Rethinking the U-Net Architecture for Multimodal Biomedical Image Segmentation](https://mlsanity.com/paper/1902.04049/) (2019)
- [Medical Image Segmentation Review: The success of U-Net](https://mlsanity.com/paper/2211.14830/) (2022)
- [Data augmentation using learned transformations for one-shot medical image segmentation](https://mlsanity.com/paper/1902.09383/) (2019)
- [GridMask Data Augmentation](https://mlsanity.com/paper/2001.04086/) (2020)
- [Multimodal Autoregressive Pre-training of Large Vision Encoders](https://mlsanity.com/paper/2411.14402/) (2024)
- [SegDINO: An Efficient Design for Medical and Natural Image Segmentation with DINO-V3](https://mlsanity.com/paper/2509.00833/) (2025)
- [AnatoMask: Enhancing Medical Image Segmentation with Reconstruction-guided Self-masking](https://mlsanity.com/paper/2407.06468/) (2024)

## Built on by (most cited first, 3 of 3)

- [LUMOS: Latent Universal Medical Priors for Segmentation](https://mlsanity.com/paper/2603.01115/) (2026)
- [HD-DinoMoE: A Class-Aware Hierarchical Dual Mixture-of-Experts Network for Scleral Anomaly Segmentation in Complex Acquisition Scenarios](https://mlsanity.com/paper/2606.04888/) (2026)
- [DINO-3DRA: Leveraging 2D Foundation Model Semantics for 3D Cerebral Aneurysm Segmentation](https://mlsanity.com/paper/2608.07767/) (2026)

## Abstract (arXiv)

Deep learning-based automatic medical image segmentation plays a critical role in clinical diagnosis and treatment planning but remains challenging in few-shot scenarios due to the scarcity of annotated training data. Recently, self-supervised foundation models such as DINOv3, which were trained on large natural image datasets, have shown strong potential for dense feature extraction that can help with the few-shot learning challenge. Yet, their direct application to medical images is hindered by domain differences. In this work, we propose DINO-AugSeg, a novel framework that leverages DINOv3 features to address the few-shot medical image segmentation challenge. Specifically, we introduce WT-Aug, a wavelet-based feature-level augmentation module that enriches the diversity of DINOv3-extracted features by perturbing frequency components, and CG-Fuse, a contextual information-guided fusion module that exploits cross-attention to integrate semantic-rich low-resolution features with spatially detailed high-resolution features. Extensive experiments on six public benchmarks spanning five imaging modalities, including MRI, CT, ultrasound, endoscopy, and dermoscopy, demonstrate that DINO-AugSeg consistently outperforms existing methods under limited-sample conditions. The results highlight the effectiveness of incorporating wavelet-domain augmentation and contextual fusion for robust feature representation, suggesting DINO-AugSeg as a promising direction for advancing few-shot medical image segmentation. Code and data will be made available on https://github.com/apple1986/DINO-AugSeg.