# Operator learning for models of tear film breakup

arXiv: https://arxiv.org/abs/2601.08001 · HTML: https://mlsanity.com/paper/2601.08001/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 12 of its 60 references that are in the map.
- First posted on arXiv 12 Jan 2026.

## Builds on (most cited first, 12 of 12)

- [Neural Ordinary Differential Equations](https://mlsanity.com/paper/1806.07366/) (2018)
- [Fourier Neural Operator for Parametric Partial Differential Equations](https://mlsanity.com/paper/2010.08895/) (2020)
- [Fourier Features Let Networks Learn High Frequency Functions in Low Dimensional Domains](https://mlsanity.com/paper/2006.10739/) (2020)
- [DeepONet: Learning nonlinear operators for identifying differential equations based on the universal approximation theorem of operators](https://mlsanity.com/paper/1910.03193/) (2019)
- [Scientific Machine Learning through Physics-Informed Neural Networks: Where we are and What's next](https://mlsanity.com/paper/2201.05624/) (2022)
- [Physics-Informed Neural Operator for Learning Partial Differential Equations](https://mlsanity.com/paper/2111.03794/) (2021)
- [Neural Operator: Learning Maps Between Function Spaces](https://mlsanity.com/paper/2108.08481/) (2021)
- [Universal Differential Equations for Scientific Machine Learning](https://mlsanity.com/paper/2001.04385/) (2020)
- [On the eigenvector bias of Fourier feature networks: From regression to solving multi-scale PDEs with physics-informed neural networks](https://mlsanity.com/paper/2012.10047/) (2020)
- [On Neural Differential Equations](https://mlsanity.com/paper/2202.02435/) (2022)
- [Multifidelity deep neural operators for efficient learning of partial differential equations with application to fast inverse design of nanoscale heat transport](https://mlsanity.com/paper/2204.06684/) (2022)
- [Operator learning with PCA-Net: upper and lower complexity bounds](https://mlsanity.com/paper/2303.16317/) (2023)

## Abstract (arXiv)

Tear film (TF) breakup is a key driver of understanding dry eye disease, yet estimating TF thickness and osmolarity from fluorescence (FL) imaging typically requires solving computationally expensive inverse problems. We propose an operator learning framework that replaces traditional inverse solvers with neural operators trained on simulated TF dynamics. This approach offers a scalable path toward rapid, data-driven analysis of tear film dynamics.