# SafePro: Evaluating the Safety of Professional-Level AI Agents

arXiv: https://arxiv.org/abs/2601.06663 · HTML: https://mlsanity.com/paper/2601.06663/

## Key facts

- Cited by 10 papers in the map (data through 14 Oct 2026).
- Placed in Agent threats, guardrails and governance, one of 16 directions in LLM agents and tool use.
- Builds on 22 of its 35 references that are in the map.
- First posted on arXiv 10 Jan 2026.

## Placed in

- LLM agents and tool use / [Agent threats, guardrails and governance](https://mlsanity.com/agents/agent-threats-guardrails-and-governance/)
- LLM safety and security / [Safety alignment, refusal and guardrails](https://mlsanity.com/safety/safety-alignment-refusal-and-guardrails/)

## Builds on (most cited first, 22 of 22)

- [SWE-bench: Can Language Models Resolve Real-World GitHub Issues?](https://mlsanity.com/paper/2310.06770/) (2023)
- [ToolLLM: Facilitating Large Language Models to Master 16000+ Real-world APIs](https://mlsanity.com/paper/2307.16789/) (2023)
- [τ-bench: A Benchmark for Tool-Agent-User Interaction in Real-World Domains](https://mlsanity.com/paper/2406.12045/) (2024)
- [Mind2Web: Towards a Generalist Agent for the Web](https://mlsanity.com/paper/2306.06070/) (2023)
- [OSWorld: Benchmarking Multimodal Agents for Open-Ended Tasks in Real Computer Environments](https://mlsanity.com/paper/2404.07972/) (2024)
- [OpenHands: An Open Platform for AI Software Developers as Generalist Agents](https://mlsanity.com/paper/2407.16741/) (2024)
- [GPT-4V(ision) is a Generalist Web Agent, if Grounded](https://mlsanity.com/paper/2401.01614/) (2024)
- [InjecAgent: Benchmarking Indirect Prompt Injections in Tool-Integrated Large Language Model Agents](https://mlsanity.com/paper/2403.02691/) (2024)
- [AgentHarm: A Benchmark for Measuring Harmfulness of LLM Agents](https://mlsanity.com/paper/2410.09024/) (2024)
- [TravelPlanner: A Benchmark for Real-World Planning with Language Agents](https://mlsanity.com/paper/2402.01622/) (2024)
- [Agent S: An Open Agentic Framework that Uses Computers Like a Human](https://mlsanity.com/paper/2410.08164/) (2024)
- [GDPval: Evaluating AI Model Performance on Real-World Economically Valuable Tasks](https://mlsanity.com/paper/2510.04374/) (2025)
- [Qwen3Guard Technical Report](https://mlsanity.com/paper/2510.14276/) (2025)
- [AI Sandbagging: Language Models can Strategically Underperform on Evaluations](https://mlsanity.com/paper/2406.07358/) (2024)
- [OS-Harm: A Benchmark for Measuring Safety of Computer Use Agents](https://mlsanity.com/paper/2506.14866/) (2025)
- [OpenAgentSafety: A Comprehensive Framework for Evaluating Real-World AI Agent Safety](https://mlsanity.com/paper/2507.06134/) (2025)
- [The MASK Benchmark: Disentangling Honesty From Accuracy in AI Systems](https://mlsanity.com/paper/2503.03750/) (2025)
- [SHADE-Arena: Evaluating Sabotage and Monitoring in LLM Agents](https://mlsanity.com/paper/2506.15740/) (2025)
- [AgentVigil: Generic Black-Box Red-teaming for Indirect Prompt Injection against LLM Agents](https://mlsanity.com/paper/2505.05849/) (2025)
- [Remote Labor Index: Measuring AI Automation of Remote Work](https://mlsanity.com/paper/2510.26787/) (2025)
- [SafeScientist: Toward Risk-Aware Scientific Discoveries by LLM Agents](https://mlsanity.com/paper/2505.23559/) (2025)
- [SIRAJ: Diverse and Efficient Red-Teaming for LLM Agents via Distilled Structured Reasoning](https://mlsanity.com/paper/2510.26037/) (2025)

## Built on by (most cited first, 10 of 10)

- [Your Agent is More Brittle Than You Think: Uncovering Indirect Injection Vulnerabilities in Agentic LLMs](https://mlsanity.com/paper/2604.03870/) (2026)
- [Taxonomy and Consistency Analysis of Safety Benchmarks for AI Agents](https://mlsanity.com/paper/2605.16282/) (2026)
- [Mind the GAP: Text Safety Does Not Transfer to Tool-Call Safety in LLM Agents](https://mlsanity.com/paper/2602.16943/) (2026)
- [From Reward-Hack Activations to Agentic Risk States: Context-Calibrated Mechanistic Monitoring in LLM Agents](https://mlsanity.com/paper/2606.06223/) (2026)
- [Don't Make Models Guess Security and Safety: Symbolic Guardrails for Domain-Specific AI Agents](https://mlsanity.com/paper/2604.15579/) (2026)
- [HARP: Measuring Harm Amplification in Multi-Agent LLM Systems](https://mlsanity.com/paper/2605.27489/) (2026)
- [Agent Hacks Agent: Autoresearch for Production-Agent Red-Teaming](https://mlsanity.com/paper/2607.11698/) (2026)
- [RAIL Guard: Closing the Evaluation-to-Remediation Gap in Responsible AI for LLM Agents](https://mlsanity.com/paper/2607.16215/) (2026)
- [AtomRec: Evolving Atomic Memory for Agentic Recommendation](https://mlsanity.com/paper/2609.04882/) (2026)
- ["You're Right, Let Me Fix It": How LLM Agents Damage Correct Work When Falsely Accused](https://mlsanity.com/paper/2609.32616/) (2026)

## Abstract (arXiv)

Large language model-based agents are rapidly evolving from simple conversational assistants into autonomous systems capable of performing complex, professional-level tasks in various domains. While these advancements promise significant productivity gains, they also introduce critical safety risks that remain under-explored. Existing safety evaluations primarily focus on simple, daily assistance tasks, failing to capture the intricate decision-making processes and potential consequences of misaligned behaviors in professional settings. To address this gap, we introduce SafePro, a comprehensive benchmark designed to evaluate the safety alignment of AI agents performing professional activities. SafePro features a dataset of high-complexity tasks across diverse professional domains with safety risks, developed through a rigorous iterative creation and review process. Our evaluation of state-of-the-art AI models reveals significant safety vulnerabilities and uncovers new unsafe behaviors in professional contexts. We further show that these models exhibit both insufficient safety judgment and weak safety alignment when executing complex professional tasks. In addition, we investigate safety mitigation strategies for improving agent safety in these scenarios and observe encouraging improvements. Together, our findings highlight the urgent need for robust safety mechanisms tailored to the next generation of professional AI agents.