# FedKDX: Federated Learning with Negative Knowledge Distillation for Enhanced Healthcare AI Systems

arXiv: https://arxiv.org/abs/2601.04587 · HTML: https://mlsanity.com/paper/2601.04587/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Federated, robust and private distillation, one of 12 directions in Knowledge distillation.
- Builds on 10 of its 21 references that are in the map.
- First posted on arXiv 8 Jan 2026.

## Placed in

- Knowledge distillation / [Federated, robust and private distillation](https://mlsanity.com/distill/federated-robust-and-private-distillation/)

## Builds on (most cited first, 10 of 10)

- [A Simple Framework for Contrastive Learning of Visual Representations](https://mlsanity.com/paper/2002.05709/) (2020)
- [Distilling the Knowledge in a Neural Network](https://mlsanity.com/paper/1503.02531/) (2015)
- [Communication-Efficient Learning of Deep Networks from Decentralized Data](https://mlsanity.com/paper/1602.05629/) (2016)
- [Federated Optimization in Heterogeneous Networks](https://mlsanity.com/paper/1812.06127/) (2018)
- [On the Convergence of FedAvg on Non-IID Data](https://mlsanity.com/paper/1907.02189/) (2019)
- [Model-Contrastive Federated Learning](https://mlsanity.com/paper/2103.16257/) (2021)
- [The Future of Digital Health with Federated Learning](https://mlsanity.com/paper/2003.08119/) (2020)
- [Personalized Federated Learning with First Order Model Optimization](https://mlsanity.com/paper/2012.08565/) (2020)
- [FedKD: Communication Efficient Federated Learning via Knowledge Distillation](https://mlsanity.com/paper/2108.13323/) (2021)
- [Federated Transfer Learning: concept and applications](https://mlsanity.com/paper/2010.15561/) (2020)

## Abstract (arXiv)

This paper introduces FedKDX, a federated learning framework that addresses limitations in healthcare AI through Negative Knowledge Distillation (NKD). Unlike existing approaches that focus solely on positive knowledge transfer, FedKDX captures both target and non-target information to improve model generalization in healthcare applications. The framework integrates multiple knowledge transfer techniques--including traditional knowledge distillation, contrastive learning, and NKD--within a unified architecture that maintains privacy while reducing communication costs. Through experiments on healthcare datasets (SLEEP, UCI-HAR, and PAMAP2), FedKDX demonstrates improved accuracy (up to 2.53% over state-of-the-art methods), faster convergence, and better performance on non-IID data distributions. Theoretical analysis supports NKD's contribution to addressing statistical heterogeneity in distributed healthcare data. The approach shows promise for privacy-sensitive medical applications under regulatory frameworks like HIPAA and GDPR, offering a balanced solution between performance and practical implementation requirements in decentralized healthcare settings. The code and model are available at https://github.com/phamdinhdat-ai/Fed_2024.