# ULS+: Data-driven Model Adaptation Enhances Lesion Segmentation

arXiv: https://arxiv.org/abs/2601.02988 · HTML: https://mlsanity.com/paper/2601.02988/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 3 of its 12 references that are in the map.
- First posted on arXiv 6 Jan 2026.

## Builds on (most cited first, 3 of 3)

- [The Medical Segmentation Decathlon](https://mlsanity.com/paper/2106.05735/) (2021)
- [The ULS23 Challenge: a Baseline Model and Benchmark Dataset for 3D Universal Lesion Segmentation in Computed Tomography](https://mlsanity.com/paper/2406.05231/) (2024)
- [MSWAL: 3D Multi-class Segmentation of Whole Abdominal Lesions Dataset](https://mlsanity.com/paper/2503.13560/) (2025)

## Abstract (arXiv)

In this study, we present ULS+, an enhanced version of the Universal Lesion Segmentation (ULS) model. The original ULS model segments lesions across the whole body in CT scans given volumes of interest (VOIs) centered around a click-point. Since its release, several new public datasets have become available that can further improve model performance. ULS+ incorporates these additional datasets and uses smaller input image sizes, resulting in higher accuracy and faster inference. We compared ULS and ULS+ using the Dice score and robustness to click-point location on the ULS23 Challenge test data and a subset of the Longitudinal-CT dataset. In all comparisons, ULS+ significantly outperformed ULS. Additionally, ULS+ ranks first on the ULS23 Challenge test-phase leaderboard. By maintaining a cycle of data-driven updates and clinical validation, ULS+ establishes a foundation for robust and clinically relevant lesion segmentation models.