# Nodule-DETR: A Novel DETR Architecture with Frequency-Channel Attention for Ultrasound Thyroid Nodule Detection

arXiv: https://arxiv.org/abs/2601.01908 · HTML: https://mlsanity.com/paper/2601.01908/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 17 of its 45 references that are in the map.
- First posted on arXiv 5 Jan 2026.

## Builds on (most cited first, 17 of 17)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [Faster R-CNN: Towards Real-Time Object Detection with Region Proposal Networks](https://mlsanity.com/paper/1506.01497/) (2015)
- [End-to-End Object Detection with Transformers](https://mlsanity.com/paper/2005.12872/) (2020)
- [Deformable DETR: Deformable Transformers for End-to-End Object Detection](https://mlsanity.com/paper/2010.04159/) (2020)
- [SSD: Single Shot MultiBox Detector](https://mlsanity.com/paper/1512.02325/) (2015)
- [Rich feature hierarchies for accurate object detection and semantic segmentation](https://mlsanity.com/paper/1311.2524/) (2013)
- [YOLOv7: Trainable bag-of-freebies sets new state-of-the-art for real-time object detectors](https://mlsanity.com/paper/2207.02696/) (2022)
- [Spatial Pyramid Pooling in Deep Convolutional Networks for Visual Recognition](https://mlsanity.com/paper/1406.4729/) (2014)
- [DAB-DETR: Dynamic Anchor Boxes are Better Queries for DETR](https://mlsanity.com/paper/2201.12329/) (2022)
- [DN-DETR: Accelerate DETR Training by Introducing Query DeNoising](https://mlsanity.com/paper/2203.01305/) (2022)
- [Intriguing Properties of Vision Transformers](https://mlsanity.com/paper/2105.10497/) (2021)
- [YOLOv11: An Overview of the Key Architectural Enhancements](https://mlsanity.com/paper/2410.17725/) (2024)
- [Reduce Information Loss in Transformers for Pluralistic Image Inpainting](https://mlsanity.com/paper/2205.05076/) (2022)
- [Object Detection for Medical Image Analysis: Insights from the RT-DETR Model](https://mlsanity.com/paper/2501.16469/) (2025)
- [Lung-DETR: Deformable Detection Transformer for Sparse Lung Nodule Anomaly Detection](https://mlsanity.com/paper/2409.05200/) (2024)
- [Understanding differences in applying DETR to natural and medical images](https://mlsanity.com/paper/2405.17677/) (2024)

## Abstract (arXiv)

Thyroid cancer is the most common endocrine malignancy, and its incidence is rising globally. While ultrasound is the preferred imaging modality for detecting thyroid nodules, its diagnostic accuracy is often limited by challenges such as low image contrast and blurred nodule boundaries. To address these issues, we propose Nodule-DETR, a novel detection transformer (DETR) architecture designed for robust thyroid nodule detection in ultrasound images. Nodule-DETR introduces three key innovations: a Multi-Spectral Frequency-domain Channel Attention (MSFCA) module that leverages frequency analysis to enhance features of low-contrast nodules; a Hierarchical Feature Fusion (HFF) module for efficient multi-scale integration; and Multi-Scale Deformable Attention (MSDA) to flexibly capture small and irregularly shaped nodules. We conducted extensive experiments on a clinical dataset of real-world thyroid ultrasound images. The results demonstrate that Nodule-DETR achieves state-of-the-art performance, outperforming the baseline model by a significant margin of 0.149 in mAP@0.5:0.95. The superior accuracy of Nodule-DETR highlights its significant potential for clinical application as an effective tool in computer-aided thyroid diagnosis. The code of work is available at https://github.com/wjj1wjj/Nodule-DETR.