# Enhancing Histopathological Image Classification via Integrated HOG and Deep Features with Robust Noise Performance

arXiv: https://arxiv.org/abs/2601.01056 · HTML: https://mlsanity.com/paper/2601.01056/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 5 of its 30 references that are in the map.
- First posted on arXiv 3 Jan 2026.

## Builds on (most cited first, 5 of 5)

- [ImageNet Large Scale Visual Recognition Challenge](https://mlsanity.com/paper/1409.0575/) (2014)
- [Lung and Colon Cancer Histopathological Image Dataset (LC25000)](https://mlsanity.com/paper/1912.12142/) (2019)
- [Prediction of lung and colon cancer through analysis of histopathological images by utilizing Pre-trained CNN models with visualization of class activation and saliency maps](https://mlsanity.com/paper/2103.12155/) (2021)
- [Classification of Histopathology Images of Lung Cancer Using Convolutional Neural Network (CNN)](https://mlsanity.com/paper/2112.13553/) (2021)
- [Ensembling Handcrafted Features with Deep Features: An Analytical Study for Classification of Routine Colon Cancer Histopathological Nuclei Images](https://mlsanity.com/paper/2202.10694/) (2022)

## Abstract (arXiv)

The era of digital pathology has advanced histopathological examinations, making automated image analysis essential in clinical practice. This study evaluates the classification performance of machine learning and deep learning models on the LC25000 dataset, which includes five classes of histopathological images. We used the fine-tuned InceptionResNet-v2 network both as a classifier and for feature extraction. Our results show that the fine-tuned InceptionResNet-v2 achieved a classification accuracy of 96.01% and an average AUC of 96.8%. Models trained on deep features from InceptionResNet-v2 outperformed those using only the pre-trained network, with the Neural Network model achieving an AUC of 99.99% and accuracy of 99.84%. Evaluating model robustness under varying SNR conditions revealed that models using deep features exhibited greater resilience, particularly GBM and KNN. The combination of HOG and deep features showed enhanced performance, however, less so in noisy environments.