# The Impact of Lesion Focus on the Performance of AI-Based Melanoma Classification

arXiv: https://arxiv.org/abs/2601.00355 · HTML: https://mlsanity.com/paper/2601.00355/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 11 of its 23 references that are in the map.
- First posted on arXiv 1 Jan 2026.

## Builds on (most cited first, 11 of 11)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Grad-CAM: Visual Explanations from Deep Networks via Gradient-based Localization](https://mlsanity.com/paper/1610.02391/) (2016)
- [Rethinking the Inception Architecture for Computer Vision](https://mlsanity.com/paper/1512.00567/) (2015)
- [You Only Look Once: Unified, Real-Time Object Detection](https://mlsanity.com/paper/1506.02640/) (2015)
- [RISE: Randomized Input Sampling for Explanation of Black-box Models](https://mlsanity.com/paper/1806.07421/) (2018)
- [Skin Lesion Analysis Toward Melanoma Detection: A Challenge at the 2017 International Symposium on Biomedical Imaging (ISBI), Hosted by the International Skin Imaging Collaboration (ISIC)](https://mlsanity.com/paper/1710.05006/) (2017)
- [BEiT v2: Masked Image Modeling with Vector-Quantized Visual Tokenizers](https://mlsanity.com/paper/2208.06366/) (2022)
- [BCN20000: Dermoscopic Lesions in the Wild](https://mlsanity.com/paper/1908.02288/) (2019)
- [Look at the Variance! Efficient Black-box Explanations with Sobol-based Sensitivity Analysis](https://mlsanity.com/paper/2111.04138/) (2021)
- [Xplique: A Deep Learning Explainability Toolbox](https://mlsanity.com/paper/2206.04394/) (2022)
- [The Fast and Accurate Approach to Detection and Segmentation of Melanoma Skin Cancer using Fine-tuned Yolov3 and SegNet Based on Deep Transfer Learning](https://mlsanity.com/paper/2210.05167/) (2022)

## Abstract (arXiv)

Melanoma is the most lethal subtype of skin cancer, and early and accurate detection of this disease can greatly improve patients' outcomes. Although machine learning models, especially convolutional neural networks (CNNs), have shown great potential in automating melanoma classification, their diagnostic reliability still suffers due to inconsistent focus on lesion areas. In this study, we analyze the relationship between lesion attention and diagnostic performance, involving masked images, bounding box detection, and transfer learning. We used multiple explainability and sensitivity analysis approaches to investigate how well models aligned their attention with lesion areas and how this alignment correlated with precision, recall, and F1-score. Results showed that models with a higher focus on lesion areas achieved better diagnostic performance, suggesting the potential of interpretable AI in medical diagnostics. This study provides a foundation for developing more accurate and trustworthy melanoma classification models in the future.