# IntraStyler: Intra-Domain Style Synthesis for Cross-Modality MRI Domain Adaptation

arXiv: https://arxiv.org/abs/2601.00212 · HTML: https://mlsanity.com/paper/2601.00212/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 17 of its 22 references that are in the map.
- First posted on arXiv 1 Jan 2026.

## Builds on (most cited first, 17 of 17)

- [A Style-Based Generator Architecture for Generative Adversarial Networks](https://mlsanity.com/paper/1812.04948/) (2018)
- [Arbitrary Style Transfer in Real-time with Adaptive Instance Normalization](https://mlsanity.com/paper/1703.06868/) (2017)
- [StarGAN v2: Diverse Image Synthesis for Multiple Domains](https://mlsanity.com/paper/1912.01865/) (2019)
- [Contrastive Learning for Unpaired Image-to-Image Translation](https://mlsanity.com/paper/2007.15651/) (2020)
- [A Learned Representation For Artistic Style](https://mlsanity.com/paper/1610.07629/) (2016)
- [Active Learning on a Budget: Opposite Strategies Suit High and Low Budgets](https://mlsanity.com/paper/2202.02794/) (2022)
- [Dynamic Instance Normalization for Arbitrary Style Transfer](https://mlsanity.com/paper/1911.06953/) (2019)
- [CrossMoDA 2021 challenge: Benchmark of Cross-Modality Domain Adaptation techniques for Vestibular Schwannoma and Cochlea Segmentation](https://mlsanity.com/paper/2201.02831/) (2022)
- [QS-Attn: Query-Selected Attention for Contrastive Learning in I2I Translation](https://mlsanity.com/paper/2203.08483/) (2022)
- [COSMOS: Cross-Modality Unsupervised Domain Adaptation for 3D Medical Image Segmentation based on Target-aware Domain Translation and Iterative Self-Training](https://mlsanity.com/paper/2203.16557/) (2022)
- [Unsupervised Domain Adaptation in Semantic Segmentation Based on Pixel Alignment and Self-Training](https://mlsanity.com/paper/2109.14219/) (2021)
- [Cross-modal tumor segmentation using generative blending augmentation and self training](https://mlsanity.com/paper/2304.01705/) (2023)
- [Enhancing Data Diversity for Self-training Based Unsupervised Cross-modality Vestibular Schwannoma and Cochlea Segmentation](https://mlsanity.com/paper/2209.11879/) (2022)
- [Learning Site-specific Styles for Multi-institutional Unsupervised Cross-modality Domain Adaptation](https://mlsanity.com/paper/2311.12437/) (2023)
- [A 3D Multi-Style Cross-Modality Segmentation Framework for Segmenting Vestibular Schwannoma and Cochlea](https://mlsanity.com/paper/2311.11578/) (2023)
- [Fine-Grained Unsupervised Cross-Modality Domain Adaptation for Vestibular Schwannoma Segmentation](https://mlsanity.com/paper/2311.15090/) (2023)
- [crossMoDA Challenge: Evolution of Cross-Modality Domain Adaptation Techniques for Vestibular Schwannoma and Cochlea Segmentation from 2021 to 2023](https://mlsanity.com/paper/2506.12006/) (2025)

## Abstract (arXiv)

Segmentation of vestibular schwannoma and cochlea from T2 MRI is clinically important yet annotation-intensive. Domain adaptation (DA) has been widely adopted to bridge the gap between labeled contrast-enhanced T1 and unlabeled T2 datasets. While existing methods focus on cross-domain alignment, intra-domain variability within the target domain remains largely overlooked. Images from the same domain may vary substantially due to different scanners, field strengths, and acquisition protocols. Ignoring this variability produces homogeneous synthetic images that limit the generalizability of downstream segmentation models. To address this, we propose IntraStyler, a 3D unpaired image translation method that automatically discovers fine-grained intra-domain styles without any predefined sub-domains, and synthesizes diverse target domain images using per-image style references. To this end, we design a 3D style encoder trained with a novel contrastive learning objective to extract style-only embeddings disentangled from anatomy. IntraStyler is built upon the 1st place CrossMoDA challenge solution and further advances it, generating more diverse synthetic data and achieving more reliable downstream segmentation. Code is available at https://github.com/MedICL-VU/IntraStyler.