# AI Meets Brain: Memory Systems from Cognitive Neuroscience to Autonomous Agents

arXiv: https://arxiv.org/abs/2512.23343 · HTML: https://mlsanity.com/paper/2512.23343/

## Key facts

- Cited by 12 papers in the map (data through 14 Oct 2026).
- Placed in Agent memory systems, one of 16 directions in LLM agents and tool use.
- Builds on 172 of its 400 references that are in the map.
- First posted on arXiv 29 Dec 2025.

## Placed in

- LLM agents and tool use / [Agent memory systems](https://mlsanity.com/agents/agent-memory-systems/)

## Builds on (most cited first, 30 of 172)

- [Gemini 2.5: Pushing the Frontier with Advanced Reasoning, Multimodality, Long Context, and Next Generation Agentic Capabilities](https://mlsanity.com/paper/2507.06261/) (2025)
- [Retrieval-Augmented Generation for Large Language Models: A Survey](https://mlsanity.com/paper/2312.10997/) (2023)
- [MemGPT: Towards LLMs as Operating Systems](https://mlsanity.com/paper/2310.08560/) (2023)
- [RULER: What's the Real Context Size of Your Long-Context Language Models?](https://mlsanity.com/paper/2404.06654/) (2024)
- [A-MEM: Agentic Memory for LLM Agents](https://mlsanity.com/paper/2502.12110/) (2025)
- [A Survey on Multimodal Large Language Models](https://mlsanity.com/paper/2306.13549/) (2023)
- [Training Large Language Models to Reason in a Continuous Latent Space](https://mlsanity.com/paper/2412.06769/) (2024)
- [Mem0: Building Production-Ready AI Agents with Scalable Long-Term Memory](https://mlsanity.com/paper/2504.19413/) (2025)
- [Extending Context Window of Large Language Models via Positional Interpolation](https://mlsanity.com/paper/2306.15595/) (2023)
- [A Survey on the Memory Mechanism of Large Language Model based Agents](https://mlsanity.com/paper/2404.13501/) (2024)
- [Agentic Context Engineering: Evolving Contexts for Self-Improving Language Models](https://mlsanity.com/paper/2510.04618/) (2025)
- [Memory in the Age of AI Agents](https://mlsanity.com/paper/2512.13564/) (2025)
- [ReasoningBank: Scaling Agent Self-Evolving with Reasoning Memory](https://mlsanity.com/paper/2509.25140/) (2025)
- [Gated Attention for Large Language Models: Non-linearity, Sparsity, and Attention-Sink-Free](https://mlsanity.com/paper/2505.06708/) (2025)
- [Evaluating Memory in LLM Agents via Incremental Multi-Turn Interactions](https://mlsanity.com/paper/2507.05257/) (2025)
- [MemAgent: Reshaping Long-Context LLM with Multi-Conv RL-based Memory Agent](https://mlsanity.com/paper/2507.02259/) (2025)
- [MEM1: Learning to Synergize Memory and Reasoning for Efficient Long-Horizon Agents](https://mlsanity.com/paper/2506.15841/) (2025)
- [Memory-R1: Enhancing Large Language Model Agents to Manage and Utilize Memories via Reinforcement Learning](https://mlsanity.com/paper/2508.19828/) (2025)
- [VideoAgent: A Memory-augmented Multimodal Agent for Video Understanding](https://mlsanity.com/paper/2403.11481/) (2024)
- [OS-Copilot: Towards Generalist Computer Agents with Self-Improvement](https://mlsanity.com/paper/2402.07456/) (2024)
- [SkillWeaver: Web Agents can Self-Improve by Discovering and Honing Skills](https://mlsanity.com/paper/2504.07079/) (2025)
- [LightMem: Lightweight and Efficient Memory-Augmented Generation](https://mlsanity.com/paper/2510.18866/) (2025)
- [Know Me, Respond to Me: Benchmarking LLMs for Dynamic User Profiling and Personalized Responses at Scale](https://mlsanity.com/paper/2504.14225/) (2025)
- [A Survey of Self-Evolving Agents: What, When, How, and Where to Evolve on the Path to Artificial Super Intelligence](https://mlsanity.com/paper/2507.21046/) (2025)
- [Flash-VStream: Memory-Based Real-Time Understanding for Long Video Streams](https://mlsanity.com/paper/2406.08085/) (2024)
- [WebAgent-R1: Training Web Agents via End-to-End Multi-Turn Reinforcement Learning](https://mlsanity.com/paper/2505.16421/) (2025)
- [Dynamic Cheatsheet: Test-Time Learning with Adaptive Memory](https://mlsanity.com/paper/2504.07952/) (2025)
- [Context as Memory: Scene-Consistent Interactive Long Video Generation with Memory Retrieval](https://mlsanity.com/paper/2506.03141/) (2025)
- [Memory OS of AI Agent](https://mlsanity.com/paper/2506.06326/) (2025)
- [Scaling Long-Horizon LLM Agent via Context-Folding](https://mlsanity.com/paper/2510.11967/) (2025)

## Built on by (most cited first, 12 of 12)

- [A Survey of Agent Memory in the Second Half: Towards Self-Evolving and Long-Horizon Agents](https://mlsanity.com/paper/2602.06052/) (2026)
- [A Survey on Long-Term Memory Security in LLM Agents: Attacks, Defenses, and Governance Across the Memory Lifecycle](https://mlsanity.com/paper/2604.16548/) (2026)
- [Beyond Static Summarization: Proactive Memory Extraction for LLM Agents](https://mlsanity.com/paper/2601.04463/) (2026)
- [The Evolution of Tool Use in LLM Agents: From Single-Tool Call to Multi-Tool Orchestration](https://mlsanity.com/paper/2603.22862/) (2026)
- [Fine-Mem: Fine-Grained Feedback Alignment for Long-Horizon Memory Management](https://mlsanity.com/paper/2601.08435/) (2026)
- [HeLa-Mem: Hebbian Learning and Associative Memory for LLM Agents](https://mlsanity.com/paper/2604.16839/) (2026)
- [Scaling Self-Evolving Agents via Parametric Memory](https://mlsanity.com/paper/2606.04536/) (2026)
- [A Systematic Investigation of Document Chunking Strategies and Embedding Sensitivity](https://mlsanity.com/paper/2603.06976/) (2026)
- [M3Eval: Multi-Modal Memory Evaluation through Cognitively-Grounded Video Tasks](https://mlsanity.com/paper/2606.05008/) (2026)
- [SRTJ: Self-Evolving Rule-Driven Training-Free LLM Jailbreaking](https://mlsanity.com/paper/2605.00974/) (2026)
- [OpenClaw and Ollama in Agentic AI: Toward Fully Autonomous and Scalable AI Agent Systems](https://mlsanity.com/paper/2607.28629/) (2026)
- [VeriPhy: Agentic Physical Reasoning for World Model Evaluation and Refinement](https://mlsanity.com/paper/2609.03153/) (2026)

## Abstract (arXiv)

Memory serves as the pivotal nexus bridging past and future, providing both humans and AI systems with invaluable concepts and experience to navigate complex tasks. Recent research on autonomous agents has increasingly focused on designing efficient memory workflows by drawing on cognitive neuroscience. However, constrained by interdisciplinary barriers, existing works struggle to assimilate the essence of human memory mechanisms. To bridge this gap, we systematically synthesizes interdisciplinary knowledge of memory, connecting insights from cognitive neuroscience with LLM-driven agents. Specifically, we first elucidate the definition and function of memory along a progressive trajectory from cognitive neuroscience through LLMs to agents. We then provide a comparative analysis of memory taxonomy, storage mechanisms, and the complete management lifecycle from both biological and artificial perspectives. Subsequently, we review the mainstream benchmarks for evaluating agent memory. Additionally, we explore memory security from dual perspectives of attack and defense. Finally, we envision future research directions, with a focus on multimodal memory systems and skill acquisition.