# Meta-information Guided Cross-domain Synergistic Diffusion Model for Low-dose PET Reconstruction

arXiv: https://arxiv.org/abs/2512.22237 · HTML: https://mlsanity.com/paper/2512.22237/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Medical imaging and segmentation, one of 14 directions in Diffusion models.
- Builds on 28 of its 54 references that are in the map.
- First posted on arXiv 23 Dec 2025.

## Placed in

- Diffusion models / [Medical imaging and segmentation](https://mlsanity.com/diffusion/medical-imaging-and-segmentation/)

## Builds on (most cited first, 28 of 28)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [LoRA: Low-Rank Adaptation of Large Language Models](https://mlsanity.com/paper/2106.09685/) (2021)
- [Denoising Diffusion Implicit Models](https://mlsanity.com/paper/2010.02502/) (2020)
- [Visual Instruction Tuning](https://mlsanity.com/paper/2304.08485/) (2023)
- [Hierarchical Text-Conditional Image Generation with CLIP Latents](https://mlsanity.com/paper/2204.06125/) (2022)
- [Generative Adversarial Networks](https://mlsanity.com/paper/2203.00667/) (2022)
- [Image-to-Image Translation with Conditional Adversarial Networks](https://mlsanity.com/paper/1611.07004/) (2016)
- [Improved Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2102.09672/) (2021)
- [GLIDE: Towards Photorealistic Image Generation and Editing with Text-Guided Diffusion Models](https://mlsanity.com/paper/2112.10741/) (2021)
- [Improved Training of Wasserstein GANs](https://mlsanity.com/paper/1704.00028/) (2017)
- [Image Super-Resolution via Iterative Refinement](https://mlsanity.com/paper/2104.07636/) (2021)
- [RePaint: Inpainting using Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2201.09865/) (2022)
- [T2I-Adapter: Learning Adapters to Dig out More Controllable Ability for Text-to-Image Diffusion Models](https://mlsanity.com/paper/2302.08453/) (2023)
- [Palette: Image-to-Image Diffusion Models](https://mlsanity.com/paper/2111.05826/) (2021)
- [Multi-Stage Progressive Image Restoration](https://mlsanity.com/paper/2102.02808/) (2021)
- [Solving Inverse Problems in Medical Imaging with Score-Based Generative Models](https://mlsanity.com/paper/2111.08005/) (2021)
- [Measuring the Intrinsic Dimension of Objective Landscapes](https://mlsanity.com/paper/1804.08838/) (2018)
- [Contrastive Diffusion Model with Auxiliary Guidance for Coarse-to-Fine PET Reconstruction](https://mlsanity.com/paper/2308.10157/) (2023)
- [Full-dose Whole-body PET Synthesis from Low-dose PET Using High-efficiency Denoising Diffusion Probabilistic Model: PET Consistency Model](https://mlsanity.com/paper/2308.13072/) (2023)
- [Diff-Restorer: Unleashing Visual Prompts for Diffusion-based Universal Image Restoration](https://mlsanity.com/paper/2407.03636/) (2024)
- [Diffusion Transformer Model With Compact Prior for Low-dose PET Reconstruction](https://mlsanity.com/paper/2407.00944/) (2024)
- [Image2Points:A 3D Point-based Context Clusters GAN for High-Quality PET Image Reconstruction](https://mlsanity.com/paper/2402.00376/) (2024)

## Abstract (arXiv)

Low-dose PET imaging is crucial for reducing patient radiation exposure but faces challenges like noise interference, reduced contrast, and difficulty in preserving physiological details. Existing methods often neglect both projection-domain physics knowledge and patient-specific meta-information, which are critical for functional-semantic correlation mining. In this study, we introduce a meta-information guided cross-domain synergistic diffusion model (MiG-DM) that integrates comprehensive cross-modal priors to generate high-quality PET images. Specifically, a meta-information encoding module transforms clinical parameters into semantic prompts by considering patient characteristics, dose-related information, and semi-quantitative parameters, enabling cross-modal alignment between textual meta-information and image reconstruction. Additionally, the cross-domain architecture combines projection-domain and image-domain processing. In the projection domain, a specialized sinogram adapter captures global physical structures through convolution operations equivalent to global image-domain filtering. Experiments on the UDPET public dataset and clinical datasets with varying dose levels demonstrate that MiG-DM outperforms state-of-the-art methods in enhancing PET image quality and preserving physiological details.