# CellMamba: Adaptive Mamba for Accurate and Efficient Cell Detection

arXiv: https://arxiv.org/abs/2512.21803 · HTML: https://mlsanity.com/paper/2512.21803/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Placed in Mamba for medical image analysis, one of 10 directions in State-space sequence models (S4, Mamba).
- Builds on 33 of its 51 references that are in the map.
- First posted on arXiv 25 Dec 2025.

## Placed in

- State-space sequence models (S4, Mamba) / [Mamba for medical image analysis](https://mlsanity.com/ssm/mamba-for-medical-image-analysis/)

## Builds on (most cited first, 30 of 33)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [End-to-End Object Detection with Transformers](https://mlsanity.com/paper/2005.12872/) (2020)
- [Mask R-CNN](https://mlsanity.com/paper/1703.06870/) (2017)
- [Feature Pyramid Networks for Object Detection](https://mlsanity.com/paper/1612.03144/) (2016)
- [Mamba: Linear-Time Sequence Modeling with Selective State Spaces](https://mlsanity.com/paper/2312.00752/) (2023)
- [Deformable DETR: Deformable Transformers for End-to-End Object Detection](https://mlsanity.com/paper/2010.04159/) (2020)
- [Fast R-CNN](https://mlsanity.com/paper/1504.08083/) (2015)
- [Efficiently Modeling Long Sequences with Structured State Spaces](https://mlsanity.com/paper/2111.00396/) (2021)
- [Transformers are SSMs: Generalized Models and Efficient Algorithms Through Structured State Space Duality](https://mlsanity.com/paper/2405.21060/) (2024)
- [DINO: DETR with Improved DeNoising Anchor Boxes for End-to-End Object Detection](https://mlsanity.com/paper/2203.03605/) (2022)
- [Simplified State Space Layers for Sequence Modeling](https://mlsanity.com/paper/2208.04933/) (2022)
- [Combining Recurrent, Convolutional, and Continuous-time Models with Linear State-Space Layers](https://mlsanity.com/paper/2110.13985/) (2021)
- [HoVer-Net: Simultaneous Segmentation and Classification of Nuclei in Multi-Tissue Histology Images](https://mlsanity.com/paper/1812.06499/) (2018)
- [Embracing Imperfect Datasets: A Review of Deep Learning Solutions for Medical Image Segmentation](https://mlsanity.com/paper/1908.10454/) (2019)
- [Deep neural network models for computational histopathology: A survey](https://mlsanity.com/paper/1912.12378/) (2019)
- [Mamba-UNet: UNet-Like Pure Visual Mamba for Medical Image Segmentation](https://mlsanity.com/paper/2402.05079/) (2024)
- [CellViT: Vision Transformers for Precise Cell Segmentation and Classification](https://mlsanity.com/paper/2306.15350/) (2023)
- [UltraLight VM-UNet: Parallel Vision Mamba Significantly Reduces Parameters for Skin Lesion Segmentation](https://mlsanity.com/paper/2403.20035/) (2024)
- [Spatial-Mamba: Effective Visual State Space Models via Structure-aware State Fusion](https://mlsanity.com/paper/2410.15091/) (2024)
- [2DMamba: Efficient State Space Model for Image Representation with Applications on Giga-Pixel Whole Slide Image Classification](https://mlsanity.com/paper/2412.00678/) (2024)
- [Computational Pathology: A Survey Review and The Way Forward](https://mlsanity.com/paper/2304.05482/) (2023)
- [VSSD: Vision Mamba with Non-Causal State Space Duality](https://mlsanity.com/paper/2407.18559/) (2024)
- [Mamba YOLO: A Simple Baseline for Object Detection with State Space Model](https://mlsanity.com/paper/2406.05835/) (2024)
- [DoNet: Deep De-overlapping Network for Cytology Instance Segmentation](https://mlsanity.com/paper/2303.14373/) (2023)
- [MobileMamba: Lightweight Multi-Receptive Visual Mamba Network](https://mlsanity.com/paper/2411.15941/) (2024)
- [Affine-Consistent Transformer for Multi-Class Cell Nuclei Detection](https://mlsanity.com/paper/2310.14154/) (2023)
- [Artificial intelligence in digital pathology: a systematic review and meta-analysis of diagnostic test accuracy](https://mlsanity.com/paper/2306.07999/) (2023)
- [DPA-P2PNet: Deformable Proposal-aware P2PNet for Accurate Point-based Cell Detection](https://mlsanity.com/paper/2303.02602/) (2023)

## Built on by (most cited first, 1 of 1)

- [End-to-End Cell Detection via Instance-aware Graph Modeling](https://mlsanity.com/paper/2609.15354/) (2026)

## Abstract (arXiv)

Cell detection in pathological images presents unique challenges due to densely packed objects, subtle inter-class differences, and severe background clutter. In this paper, we propose CellMamba, a lightweight and accurate one-stage detector tailored for fine-grained biomedical instance detection. Built upon a VSSD backbone, CellMamba integrates CellMamba Blocks, which couple either NC-Mamba or Multi-Head Self-Attention (MSA) with a novel Triple-Mapping Adaptive Coupling (TMAC) module. TMAC enhances spatial discriminability by splitting channels into two parallel branches, equipped with dual idiosyncratic and one consensus attention map, adaptively fused to preserve local sensitivity and global consistency. Furthermore, we design an Adaptive Mamba Head that fuses multi-scale features via learnable weights for robust detection under varying object sizes. Extensive experiments on two public datasets-CoNSeP and CytoDArk0-demonstrate that CellMamba outperforms both CNN-based, Transformer-based, and Mamba-based baselines in accuracy, while significantly reducing model size and inference latency. Our results validate CellMamba as an efficient and effective solution for high-resolution cell detection.