# Foundation Model-based Evaluation of Neuropsychiatric Disorders: A Lifespan-Inclusive, Multi-Modal, and Multi-Lingual Study

arXiv: https://arxiv.org/abs/2512.20948 · HTML: https://mlsanity.com/paper/2512.20948/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 59 of its 106 references that are in the map.
- First posted on arXiv 24 Dec 2025.

## Builds on (most cited first, 30 of 59)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
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- [RoBERTa: A Robustly Optimized BERT Pretraining Approach](https://mlsanity.com/paper/1907.11692/) (2019)
- [Qwen2.5 Technical Report](https://mlsanity.com/paper/2412.15115/) (2024)
- [Robust Speech Recognition via Large-Scale Weak Supervision](https://mlsanity.com/paper/2212.04356/) (2022)
- [wav2vec 2.0: A Framework for Self-Supervised Learning of Speech Representations](https://mlsanity.com/paper/2006.11477/) (2020)
- [XLNet: Generalized Autoregressive Pretraining for Language Understanding](https://mlsanity.com/paper/1906.08237/) (2019)
- [HuBERT: Self-Supervised Speech Representation Learning by Masked Prediction of Hidden Units](https://mlsanity.com/paper/2106.07447/) (2021)
- [DeBERTa: Decoding-enhanced BERT with Disentangled Attention](https://mlsanity.com/paper/2006.03654/) (2020)
- [SimCSE: Simple Contrastive Learning of Sentence Embeddings](https://mlsanity.com/paper/2104.08821/) (2021)
- [WavLM: Large-Scale Self-Supervised Pre-Training for Full Stack Speech Processing](https://mlsanity.com/paper/2110.13900/) (2021)
- [Text Embeddings by Weakly-Supervised Contrastive Pre-training](https://mlsanity.com/paper/2212.03533/) (2022)
- [data2vec: A General Framework for Self-supervised Learning in Speech, Vision and Language](https://mlsanity.com/paper/2202.03555/) (2022)
- [Towards General Text Embeddings with Multi-stage Contrastive Learning](https://mlsanity.com/paper/2308.03281/) (2023)
- [Baichuan 2: Open Large-scale Language Models](https://mlsanity.com/paper/2309.10305/) (2023)
- [Multimodal Transformer for Unaligned Multimodal Language Sequences](https://mlsanity.com/paper/1906.00295/) (2019)
- [XLS-R: Self-supervised Cross-lingual Speech Representation Learning at Scale](https://mlsanity.com/paper/2111.09296/) (2021)
- [Tensor Fusion Network for Multimodal Sentiment Analysis](https://mlsanity.com/paper/1707.07250/) (2017)
- [Multilingual E5 Text Embeddings: A Technical Report](https://mlsanity.com/paper/2402.05672/) (2024)
- [Efficient Low-rank Multimodal Fusion with Modality-Specific Factors](https://mlsanity.com/paper/1806.00064/) (2018)
- [Balanced Multimodal Learning via On-the-fly Gradient Modulation](https://mlsanity.com/paper/2203.15332/) (2022)
- [Self-Supervised Speech Representation Learning: A Review](https://mlsanity.com/paper/2205.10643/) (2022)
- [mGTE: Generalized Long-Context Text Representation and Reranking Models for Multilingual Text Retrieval](https://mlsanity.com/paper/2407.19669/) (2024)
- [emotion2vec: Self-Supervised Pre-Training for Speech Emotion Representation](https://mlsanity.com/paper/2312.15185/) (2023)
- [Learning Factorized Multimodal Representations](https://mlsanity.com/paper/1806.06176/) (2018)
- [Memory Fusion Network for Multi-view Sequential Learning](https://mlsanity.com/paper/1802.00927/) (2018)
- [Improving Multimodal Fusion with Hierarchical Mutual Information Maximization for Multimodal Sentiment Analysis](https://mlsanity.com/paper/2109.00412/) (2021)
- [FunAudioLLM: Voice Understanding and Generation Foundation Models for Natural Interaction Between Humans and LLMs](https://mlsanity.com/paper/2407.04051/) (2024)
- [PMR: Prototypical Modal Rebalance for Multimodal Learning](https://mlsanity.com/paper/2211.07089/) (2022)
- [Alzheimer's Dementia Recognition through Spontaneous Speech: The ADReSS Challenge](https://mlsanity.com/paper/2004.06833/) (2020)

## Abstract (arXiv)

Neuropsychiatric disorders, such as Alzheimer's disease (AD), depression, and autism spectrum disorder (ASD), are characterized by linguistic and acoustic abnormalities, offering potential biomarkers for early detection. Despite the promise of multi-modal approaches, challenges like multi-lingual generalization and the absence of a unified evaluation framework persist. To address these gaps, we propose FEND (Foundation model-based Evaluation of Neuropsychiatric Disorders), a comprehensive multi-modal framework integrating speech and text modalities for detecting AD, depression, and ASD across the lifespan. Leveraging 13 multi-lingual datasets spanning English, Chinese, Greek, French, and Dutch, we systematically evaluate multi-modal fusion performance. Our results show that multi-modal fusion excels in AD and depression detection but underperforms in ASD due to dataset heterogeneity. We also identify modality imbalance as a prevalent issue, where multi-modal fusion fails to surpass the best mono-modal models. Cross-corpus experiments reveal robust performance in task- and language-consistent scenarios but noticeable degradation in multi-lingual and task-heterogeneous settings. By providing extensive benchmarks and a detailed analysis of performance-influencing factors, FEND advances the field of automated, lifespan-inclusive, and multi-lingual neuropsychiatric disorder assessment. We encourage researchers to adopt the FEND framework for fair comparisons and reproducible research.