# MAPI-GNN: Multi-Activation Plane Interaction Graph Neural Network for Multimodal Medical Diagnosis

arXiv: https://arxiv.org/abs/2512.20026 · HTML: https://mlsanity.com/paper/2512.20026/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 15 of its 50 references that are in the map.
- First posted on arXiv 23 Dec 2025.

## Builds on (most cited first, 15 of 15)

- [Semi-Supervised Classification with Graph Convolutional Networks](https://mlsanity.com/paper/1609.02907/) (2016)
- [Graph Attention Networks](https://mlsanity.com/paper/1710.10903/) (2017)
- [Inductive Representation Learning on Large Graphs](https://mlsanity.com/paper/1706.02216/) (2017)
- [A Comprehensive Survey on Graph Neural Networks](https://mlsanity.com/paper/1901.00596/) (2019)
- [Graph Neural Networks in Recommender Systems: A Survey](https://mlsanity.com/paper/2011.02260/) (2020)
- [Big Self-Supervised Models Advance Medical Image Classification](https://mlsanity.com/paper/2101.05224/) (2021)
- [Inf-Net: Automatic COVID-19 Lung Infection Segmentation from CT Images](https://mlsanity.com/paper/2004.14133/) (2020)
- [Deep-COVID: Predicting COVID-19 From Chest X-Ray Images Using Deep Transfer Learning](https://mlsanity.com/paper/2004.09363/) (2020)
- [A Survey on Graph Representation Learning Methods](https://mlsanity.com/paper/2204.01855/) (2022)
- [Deep Multi-modal Fusion of Image and Non-image Data in Disease Diagnosis and Prognosis: A Review](https://mlsanity.com/paper/2203.15588/) (2022)
- [Deep learning for temporal data representation in electronic health records: A systematic review of challenges and methodologies](https://mlsanity.com/paper/2107.09951/) (2021)
- [Multimodal Learning on Graphs for Disease Relation Extraction](https://mlsanity.com/paper/2203.08893/) (2022)
- [A Multi-modal Fusion Framework Based on Multi-task Correlation Learning for Cancer Prognosis Prediction](https://mlsanity.com/paper/2201.10353/) (2022)
- [A Multimodal Graph Neural Network Framework of Cancer Molecular Subtype Classification](https://mlsanity.com/paper/2302.12838/) (2023)
- [Neighbor Enhanced Graph Convolutional Networks for Node Classification and Recommendation](https://mlsanity.com/paper/2203.16097/) (2022)

## Abstract (arXiv)

Graph neural networks are increasingly applied to multimodal medical diagnosis for their inherent relational modeling capabilities. However, their efficacy is often compromised by the prevailing reliance on a single, static graph built from indiscriminate features, hindering the ability to model patient-specific pathological relationships. To this end, the proposed Multi-Activation Plane Interaction Graph Neural Network (MAPI-GNN) reconstructs this single-graph paradigm by learning a multifaceted graph profile from semantically disentangled feature subspaces. The framework first uncovers latent graph-aware patterns via a multi-dimensional discriminator; these patterns then guide the dynamic construction of a stack of activation graphs; and this multifaceted profile is finally aggregated and contextualized by a relational fusion engine for a robust diagnosis. Extensive experiments on two diverse tasks, comprising over 1300 patient samples, demonstrate that MAPI-GNN significantly outperforms state-of-the-art methods.