# Anatomy-R1: Enhancing Anatomy Reasoning in Multimodal Large Language Models via Anatomical Similarity Curriculum and Group Diversity Augmentation

arXiv: https://arxiv.org/abs/2512.19512 · HTML: https://mlsanity.com/paper/2512.19512/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Placed in Clinical and biomedical applications, one of 17 directions in LLM reasoning.
- Builds on 28 of its 35 references that are in the map.
- First posted on arXiv 22 Dec 2025.

## Placed in

- LLM reasoning / [Clinical and biomedical applications](https://mlsanity.com/lr/clinical-and-biomedical-applications/)
- Multimodal LLMs / vision-language models / [Medical vision-language models](https://mlsanity.com/mllm/medical-vision-language-models/)

## Builds on (most cited first, 28 of 28)

- [Chain-of-Thought Prompting Elicits Reasoning in Large Language Models](https://mlsanity.com/paper/2201.11903/) (2022)
- [DeepSeekMath: Pushing the Limits of Mathematical Reasoning in Open Language Models](https://mlsanity.com/paper/2402.03300/) (2024)
- [DeepSeek-R1: Incentivizing Reasoning Capability in LLMs via Reinforcement Learning](https://mlsanity.com/paper/2501.12948/) (2025)
- [Qwen2.5-VL Technical Report](https://mlsanity.com/paper/2502.13923/) (2025)
- [DAPO: An Open-Source LLM Reinforcement Learning System at Scale](https://mlsanity.com/paper/2503.14476/) (2025)
- [LLaVA-Med: Training a Large Language-and-Vision Assistant for Biomedicine in One Day](https://mlsanity.com/paper/2306.00890/) (2023)
- [Kimi k1.5: Scaling Reinforcement Learning with LLMs](https://mlsanity.com/paper/2501.12599/) (2025)
- [Aligning Large Multimodal Models with Factually Augmented RLHF](https://mlsanity.com/paper/2309.14525/) (2023)
- [SFT Memorizes, RL Generalizes: A Comparative Study of Foundation Model Post-training](https://mlsanity.com/paper/2501.17161/) (2025)
- [Vision-R1: Incentivizing Reasoning Capability in Multimodal Large Language Models](https://mlsanity.com/paper/2503.06749/) (2025)
- [MedCLIP: Contrastive Learning from Unpaired Medical Images and Text](https://mlsanity.com/paper/2210.10163/) (2022)
- [Visual-RFT: Visual Reinforcement Fine-Tuning](https://mlsanity.com/paper/2503.01785/) (2025)
- [RLHF-V: Towards Trustworthy MLLMs via Behavior Alignment from Fine-grained Correctional Human Feedback](https://mlsanity.com/paper/2312.00849/) (2023)
- [R1-Onevision: Advancing Generalized Multimodal Reasoning through Cross-Modal Formalization](https://mlsanity.com/paper/2503.10615/) (2025)
- [VL-Rethinker: Incentivizing Self-Reflection of Vision-Language Models with Reinforcement Learning](https://mlsanity.com/paper/2504.08837/) (2025)
- [HuatuoGPT-Vision, Towards Injecting Medical Visual Knowledge into Multimodal LLMs at Scale](https://mlsanity.com/paper/2406.19280/) (2024)
- [OmniMedVQA: A New Large-Scale Comprehensive Evaluation Benchmark for Medical LVLM](https://mlsanity.com/paper/2402.09181/) (2024)
- [MedVLM-R1: Incentivizing Medical Reasoning Capability of Vision-Language Models (VLMs) via Reinforcement Learning](https://mlsanity.com/paper/2502.19634/) (2025)
- [R1-Zero's "Aha Moment" in Visual Reasoning on a 2B Non-SFT Model](https://mlsanity.com/paper/2503.05132/) (2025)
- [GPG: A Simple and Strong Reinforcement Learning Baseline for Model Reasoning](https://mlsanity.com/paper/2504.02546/) (2025)
- [Best Practices and Lessons Learned on Synthetic Data](https://mlsanity.com/paper/2404.07503/) (2024)
- [DeepVideo-R1: Video Reinforcement Fine-Tuning via Difficulty-aware Regressive GRPO](https://mlsanity.com/paper/2506.07464/) (2025)
- [Patho-R1: A Multimodal Reinforcement Learning-Based Pathology Expert Reasoner](https://mlsanity.com/paper/2505.11404/) (2025)
- [GSCo: Towards Generalizable AI in Medicine via Generalist-Specialist Collaboration](https://mlsanity.com/paper/2404.15127/) (2024)
- [Relation-R1: Progressively Cognitive Chain-of-Thought Guided Reinforcement Learning for Unified Relation Comprehension](https://mlsanity.com/paper/2504.14642/) (2025)
- [Direct Preference Optimization for Suppressing Hallucinated Prior Exams in Radiology Report Generation](https://mlsanity.com/paper/2406.06496/) (2024)
- [MoE-Enhanced Explainable Deep Manifold Transformation for Complex Data Embedding and Visualization](https://mlsanity.com/paper/2410.19504/) (2024)
- [A Framework for Multimodal Medical Image Interaction](https://mlsanity.com/paper/2407.07015/) (2024)

## Built on by (most cited first, 1 of 1)

- [PathoSage: Towards Multi-Source Evidence Adjudication in Pathology via Experience-Aware Agentic Workflow](https://mlsanity.com/paper/2606.07549/) (2026)

## Abstract (arXiv)

Multimodal Large Language Models (MLLMs) have achieved impressive progress in natural image reasoning, yet their potential in medical imaging remains underexplored, especially in clinical anatomical surgical images. Anatomy understanding tasks demand precise understanding and clinically coherent answers, which are difficult to achieve due to the complexity of medical data and the scarcity of high-quality expert annotations. These challenges limit the effectiveness of conventional Supervised Fine-Tuning (SFT) strategies. While recent work has demonstrated that Group Relative Policy Optimization (GRPO) can enhance reasoning in MLLMs without relying on large amounts of data, we find two weaknesses that hinder GRPO's reasoning performance in anatomy recognition: 1) knowledge cannot be effectively shared between different anatomical structures, resulting in uneven information gain and preventing the model from converging, and 2) the model quickly converges to a single reasoning path, suppressing the exploration of diverse strategies. To overcome these challenges, we propose two novel methods. First, we implement a progressive learning strategy called Anatomical Similarity Curriculum Learning by controlling question difficulty via the similarity of answer choices, enabling the model to master complex problems incrementally. Second, we utilize question augmentation referred to as Group Diversity Question Augmentation to expand the model's search space for difficult queries, mitigating the tendency to produce uniform responses. Comprehensive experiments on the SGG-VQA and OmniMedVQA benchmarks show our method achieves a significant improvement across the two benchmarks, demonstrating its effectiveness in enhancing the medical reasoning capabilities of MLLMs. The code can be found in https://github.com/tomato996/Anatomy-R1