# InvCoSS: Inversion-driven Continual Self-supervised Learning in Medical Multi-modal Image Pre-training

arXiv: https://arxiv.org/abs/2512.19213 · HTML: https://mlsanity.com/paper/2512.19213/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 41 of its 57 references that are in the map.
- First posted on arXiv 22 Dec 2025.

## Builds on (most cited first, 30 of 41)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Masked Autoencoders Are Scalable Vision Learners](https://mlsanity.com/paper/2111.06377/) (2021)
- [Overcoming catastrophic forgetting in neural networks](https://mlsanity.com/paper/1612.00796/) (2016)
- [Gradient Episodic Memory for Continual Learning](https://mlsanity.com/paper/1706.08840/) (2017)
- [PackNet: Adding Multiple Tasks to a Single Network by Iterative Pruning](https://mlsanity.com/paper/1711.05769/) (2017)
- [A Comprehensive Survey of Continual Learning: Theory, Method and Application](https://mlsanity.com/paper/2302.00487/) (2023)
- [Contrastive Learning of Medical Visual Representations from Paired Images and Text](https://mlsanity.com/paper/2010.00747/) (2020)
- [Learning to Learn without Forgetting by Maximizing Transfer and Minimizing Interference](https://mlsanity.com/paper/1810.11910/) (2018)
- [The Liver Tumor Segmentation Benchmark (LiTS)](https://mlsanity.com/paper/1901.04056/) (2019)
- [Dreaming to Distill: Data-free Knowledge Transfer via DeepInversion](https://mlsanity.com/paper/1912.08795/) (2019)
- [Self-Supervised Pre-Training of Swin Transformers for 3D Medical Image Analysis](https://mlsanity.com/paper/2111.14791/) (2021)
- [Uncertainty-aware Self-ensembling Model for Semi-supervised 3D Left Atrium Segmentation](https://mlsanity.com/paper/1907.07034/) (2019)
- [Unrolled Generative Adversarial Networks](https://mlsanity.com/paper/1611.02163/) (2016)
- [Data-Free Learning of Student Networks](https://mlsanity.com/paper/1904.01186/) (2019)
- [Gland Segmentation in Colon Histology Images: The GlaS Challenge Contest](https://mlsanity.com/paper/1603.00275/) (2016)
- [Multi-Granularity Cross-modal Alignment for Generalized Medical Visual Representation Learning](https://mlsanity.com/paper/2210.06044/) (2022)
- [Self-Supervised Models are Continual Learners](https://mlsanity.com/paper/2112.04215/) (2021)
- [Always Be Dreaming: A New Approach for Data-Free Class-Incremental Learning](https://mlsanity.com/paper/2106.09701/) (2021)
- [PubMed 200k RCT: a Dataset for Sequential Sentence Classification in Medical Abstracts](https://mlsanity.com/paper/1710.06071/) (2017)
- [VoCo: A Simple-yet-Effective Volume Contrastive Learning Framework for 3D Medical Image Analysis](https://mlsanity.com/paper/2402.17300/) (2024)
- [Transferable Visual Words: Exploiting the Semantics of Anatomical Patterns for Self-supervised Learning](https://mlsanity.com/paper/2102.10680/) (2021)
- [Contrastive Model Inversion for Data-Free Knowledge Distillation](https://mlsanity.com/paper/2105.08584/) (2021)
- [Delving into Masked Autoencoders for Multi-Label Thorax Disease Classification](https://mlsanity.com/paper/2210.12843/) (2022)
- [Preservational Learning Improves Self-supervised Medical Image Models by Reconstructing Diverse Contexts](https://mlsanity.com/paper/2109.04379/) (2021)
- [Recent Advances of Continual Learning in Computer Vision: An Overview](https://mlsanity.com/paper/2109.11369/) (2021)
- [Online Continual Learning under Extreme Memory Constraints](https://mlsanity.com/paper/2008.01510/) (2020)
- [OSegNet: Operational Segmentation Network for COVID-19 Detection using Chest X-ray Images](https://mlsanity.com/paper/2202.10185/) (2022)
- [Geometric Visual Similarity Learning in 3D Medical Image Self-supervised Pre-training](https://mlsanity.com/paper/2303.00874/) (2023)
- [Continual Self-supervised Learning: Towards Universal Multi-modal Medical Data Representation Learning](https://mlsanity.com/paper/2311.17597/) (2023)

## Built on by (most cited first, 1 of 1)

- [Where to Look Matters: Rethinking Sub-Volume Sampling in 3D Medical Self-supervised Learning](https://mlsanity.com/paper/2610.13915/) (2026)

## Abstract (arXiv)

Continual self-supervised learning (CSSL) in medical imaging trains a foundation model sequentially, alleviating the need for collecting multi-modal images for joint training and offering promising improvements in downstream performance while preserving data privacy. However, most existing methods still rely on replaying data from previous stages to prevent catastrophic forgetting, which compromises privacy and limits their applicability in real-world scenarios where data transfer across sites is often restricted. In this work, we propose InvCoSS, an inversion-driven continual self-supervised learning framework for medical multi-modal image pre-training. Specifically, after training on a previous task, InvCoSS inverts the pre-trained self-supervised model to generate synthetic images that approximate the original training distribution. These synthetic images are then combined with data from the new task for joint optimization, which effectively mitigates catastrophic forgetting while strictly adhering to the constraint of no access to previous real data. Furthermore, to improve the fidelity of synthetic images, we introduce a novel InvUNet with a multi-scale fusion architecture to restore both high- and low-frequency components of the inverted images. To enhance diversity and prevent mode collapse, we design a repulsive representation-learning mechanism that encourages a diverse feature space for synthetic images without class guidance. Extensive experiments across nine downstream tasks validate the effectiveness of InvCoSS, achieving performance comparable to or even superior to prior data-replay methods while significantly reducing storage requirements and eliminating data privacy constraints.