# Mamba-Based Modality Disentanglement Network for Multi-Contrast MRI Reconstruction

arXiv: https://arxiv.org/abs/2512.19095 · HTML: https://mlsanity.com/paper/2512.19095/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Mamba for medical image analysis, one of 10 directions in State-space sequence models (S4, Mamba).
- Builds on 18 of its 48 references that are in the map.
- First posted on arXiv 22 Dec 2025.

## Placed in

- State-space sequence models (S4, Mamba) / [Mamba for medical image analysis](https://mlsanity.com/ssm/mamba-for-medical-image-analysis/)

## Builds on (most cited first, 18 of 18)

- [Swin Transformer: Hierarchical Vision Transformer using Shifted Windows](https://mlsanity.com/paper/2103.14030/) (2021)
- [Mamba: Linear-Time Sequence Modeling with Selective State Spaces](https://mlsanity.com/paper/2312.00752/) (2023)
- [Restormer: Efficient Transformer for High-Resolution Image Restoration](https://mlsanity.com/paper/2111.09881/) (2021)
- [VMamba: Visual State Space Model](https://mlsanity.com/paper/2401.10166/) (2024)
- [Convolutional Recurrent Neural Networks for Dynamic MR Image Reconstruction](https://mlsanity.com/paper/1712.01751/) (2017)
- [Compressed Sensing MRI Reconstruction using a Generative Adversarial Network with a Cyclic Loss](https://mlsanity.com/paper/1709.00753/) (2017)
- [Pan-Mamba: Effective pan-sharpening with State Space Model](https://mlsanity.com/paper/2402.12192/) (2024)
- [Task Transformer Network for Joint MRI Reconstruction and Super-Resolution](https://mlsanity.com/paper/2106.06742/) (2021)
- [Swin Transformer for Fast MRI](https://mlsanity.com/paper/2201.03230/) (2022)
- [DIMENSION: Dynamic MR Imaging with Both K-space and Spatial Prior Knowledge Obtained via Multi-Supervised Network Training](https://mlsanity.com/paper/1810.00302/) (2018)
- [Deep J-Sense: Accelerated MRI Reconstruction via Unrolled Alternating Optimization](https://mlsanity.com/paper/2103.02087/) (2021)
- [MambaMIR: An Arbitrary-Masked Mamba for Joint Medical Image Reconstruction and Uncertainty Estimation](https://mlsanity.com/paper/2402.18451/) (2024)
- [Deform-Mamba Network for MRI Super-Resolution](https://mlsanity.com/paper/2407.05969/) (2024)
- [MMR-Mamba: Multi-Modal MRI Reconstruction with Mamba and Spatial-Frequency Information Fusion](https://mlsanity.com/paper/2406.18950/) (2024)
- [Progressive Divide-and-Conquer via Subsampling Decomposition for Accelerated MRI](https://mlsanity.com/paper/2403.10064/) (2024)
- [High-Resolution Pelvic MRI Reconstruction Using a Generative Adversarial Network with Attention and Cyclic Loss](https://mlsanity.com/paper/2107.09989/) (2021)
- [MambaRecon: MRI Reconstruction with Structured State Space Models](https://mlsanity.com/paper/2409.12401/) (2024)
- [Fast MRI Reconstruction via Edge Attention](https://mlsanity.com/paper/2304.11400/) (2023)

## Abstract (arXiv)

Magnetic resonance imaging (MRI) is a cornerstone of modern clinical diagnosis, offering unparalleled soft-tissue contrast without ionizing radiation. However, prolonged scan times remain a major barrier to patient throughput and comfort. Existing accelerated MRI techniques often struggle with two key challenges: (1) failure to effectively utilize inherent K-space prior information, leading to persistent aliasing artifacts from zero-filled inputs; and (2) contamination of target reconstruction quality by irrelevant information when employing multi-contrast fusion strategies. To overcome these challenges, we present MambaMDN, a dual-domain framework for multi-contrast MRI reconstruction. Our approach first employs fully-sampled reference K-space data to complete the undersampled target data, generating structurally aligned but modality-mixed inputs. Subsequently, we develop a Mamba-based modality disentanglement network to extract and remove reference-specific features from the mixed representation. Furthermore, we introduce an iterative refinement mechanism to progressively enhance reconstruction accuracy through repeated feature purification. Extensive experiments demonstrate that MambaMDN can significantly outperform existing multi-contrast reconstruction methods.