# Generative modeling of conditional probability distributions on the level-sets of collective variables

arXiv: https://arxiv.org/abs/2512.17374 · HTML: https://mlsanity.com/paper/2512.17374/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 19 of its 52 references that are in the map.
- First posted on arXiv 19 Dec 2025.

## Builds on (most cited first, 19 of 19)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [PyTorch: An Imperative Style, High-Performance Deep Learning Library](https://mlsanity.com/paper/1912.01703/) (2019)
- [Score-Based Generative Modeling through Stochastic Differential Equations](https://mlsanity.com/paper/2011.13456/) (2020)
- [Deep Unsupervised Learning using Nonequilibrium Thermodynamics](https://mlsanity.com/paper/1503.03585/) (2015)
- [Flow Matching for Generative Modeling](https://mlsanity.com/paper/2210.02747/) (2022)
- [Generative Modeling by Estimating Gradients of the Data Distribution](https://mlsanity.com/paper/1907.05600/) (2019)
- [Neural Ordinary Differential Equations](https://mlsanity.com/paper/1806.07366/) (2018)
- [Flow Straight and Fast: Learning to Generate and Transfer Data with Rectified Flow](https://mlsanity.com/paper/2209.03003/) (2022)
- [Building Normalizing Flows with Stochastic Interpolants](https://mlsanity.com/paper/2209.15571/) (2022)
- [Flow Matching on General Geometries](https://mlsanity.com/paper/2302.03660/) (2023)
- [Riemannian Score-Based Generative Modelling](https://mlsanity.com/paper/2202.02763/) (2022)
- [Riemannian Continuous Normalizing Flows](https://mlsanity.com/paper/2006.10605/) (2020)
- [Riemannian Diffusion Models](https://mlsanity.com/paper/2208.07949/) (2022)
- [Moser Flow: Divergence-based Generative Modeling on Manifolds](https://mlsanity.com/paper/2108.08052/) (2021)
- [Matching Normalizing Flows and Probability Paths on Manifolds](https://mlsanity.com/paper/2207.04711/) (2022)
- [Generative Modeling on Manifolds Through Mixture of Riemannian Diffusion Processes](https://mlsanity.com/paper/2310.07216/) (2023)
- [Improving the Euclidean Diffusion Generation of Manifold Data by Mitigating Score Function Singularity](https://mlsanity.com/paper/2505.09922/) (2025)
- [Riemannian Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2505.04338/) (2025)
- [On finding optimal collective variables for complex systems by minimizing the deviation between effective and full dynamics](https://mlsanity.com/paper/2405.02001/) (2024)

## Abstract (arXiv)

Given a probability distribution μ in ℝd represented by data, we study in this paper the generative modeling of the corresponding conditional probability distributions on the level-sets of a collective variable xi:ℝd rightarrow ℝk, where 1 ≤ k<d. We propose a general and efficient learning approach that can learn generative models on different level-sets of xi simultaneously. To improve the learning quality on level-sets in low-probability regions, we also propose a data enrichment strategy by utilizing data from enhanced sampling techniques. We demonstrate the effectiveness of our proposed learning approach through concrete numerical examples. The proposed approach is potentially useful for the generative modeling of molecular systems in biophysics.