# Training Together, Diagnosing Better: Federated Learning for Collagen VI-Related Dystrophies

arXiv: https://arxiv.org/abs/2512.16876 · HTML: https://mlsanity.com/paper/2512.16876/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 12 of its 36 references that are in the map.
- First posted on arXiv 18 Dec 2025.

## Builds on (most cited first, 12 of 12)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
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- [Communication-Efficient Learning of Deep Networks from Decentralized Data](https://mlsanity.com/paper/1602.05629/) (2016)
- [EfficientNet: Rethinking Model Scaling for Convolutional Neural Networks](https://mlsanity.com/paper/1905.11946/) (2019)
- [XGBoost: A Scalable Tree Boosting System](https://mlsanity.com/paper/1603.02754/) (2016)
- [A Comprehensive Overview of Large Language Models](https://mlsanity.com/paper/2307.06435/) (2023)
- [Federated Learning on Non-IID Data: A Survey](https://mlsanity.com/paper/2106.06843/) (2021)
- [Multi-Institutional Deep Learning Modeling Without Sharing Patient Data: A Feasibility Study on Brain Tumor Segmentation](https://mlsanity.com/paper/1810.04304/) (2018)
- [Federated Learning for Medical Image Analysis: A Survey](https://mlsanity.com/paper/2306.05980/) (2023)
- [From Distributed Machine Learning to Federated Learning: A Survey](https://mlsanity.com/paper/2104.14362/) (2021)
- [Non-IID data in Federated Learning: A Survey with Taxonomy, Metrics, Methods, Frameworks and Future Directions](https://mlsanity.com/paper/2411.12377/) (2024)
- [A Convolutional Neural Network for the Automatic Diagnosis of Collagen VI related Muscular Dystrophies](https://mlsanity.com/paper/1901.11074/) (2019)

## Abstract (arXiv)

The application of Machine Learning (ML) to the diagnosis of rare diseases, such as collagen VI-related dystrophies (COL6-RD), is fundamentally limited by the scarcity and fragmentation of available data. Attempts to expand sampling across hospitals, institutions, or countries with differing regulations face severe privacy, regulatory, and logistical obstacles that are often difficult to overcome. The Federated Learning (FL) provides a promising solution by enabling collaborative model training across decentralized datasets while keeping patient data local and private. Here, we report a novel global FL initiative using the Sherpa.ai FL platform, which leverages FL across distributed datasets in two international organizations for the diagnosis of COL6-RD, using collagen VI immunofluorescence microscopy images from patient-derived fibroblast cultures. Our solution resulted in an ML model capable of classifying collagen VI patient images into the three primary pathogenic mechanism groups associated with COL6-RD: exon skipping, glycine substitution, and pseudoexon insertion. This new approach achieved an F1-score of 0.82, outperforming single-organization models (0.57-0.75). These results demonstrate that FL substantially improves diagnostic utility and generalizability compared to isolated institutional models. Beyond enabling more accurate diagnosis, we anticipate that this approach will support the interpretation of variants of uncertain significance and guide the prioritization of sequencing strategies to identify novel pathogenic variants.