# Efficient CPU-GPU Collaborative Inference for MoE-based LLMs on Memory-Limited Systems

arXiv: https://arxiv.org/abs/2512.16473 · HTML: https://mlsanity.com/paper/2512.16473/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Placed in Efficient MoE training and inference systems, one of 12 directions in Mixture-of-experts.
- Builds on 21 of its 29 references that are in the map.
- First posted on arXiv 18 Dec 2025.

## Placed in

- Mixture-of-experts / [Efficient MoE training and inference systems](https://mlsanity.com/moe/efficient-moe-training-and-inference-systems/)

## Builds on (most cited first, 21 of 21)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [PyTorch: An Imperative Style, High-Performance Deep Learning Library](https://mlsanity.com/paper/1912.01703/) (2019)
- [GPT-4 Technical Report](https://mlsanity.com/paper/2303.08774/) (2023)
- [The Llama 3 Herd of Models](https://mlsanity.com/paper/2407.21783/) (2024)
- [Llama 2: Open Foundation and Fine-Tuned Chat Models](https://mlsanity.com/paper/2307.09288/) (2023)
- [Measuring Massive Multitask Language Understanding](https://mlsanity.com/paper/2009.03300/) (2020)
- [Outrageously Large Neural Networks: The Sparsely-Gated Mixture-of-Experts Layer](https://mlsanity.com/paper/1701.06538/) (2017)
- [Switch Transformers: Scaling to Trillion Parameter Models with Simple and Efficient Sparsity](https://mlsanity.com/paper/2101.03961/) (2021)
- [Qwen2 Technical Report](https://mlsanity.com/paper/2407.10671/) (2024)
- [Phi-3 Technical Report: A Highly Capable Language Model Locally on Your Phone](https://mlsanity.com/paper/2404.14219/) (2024)
- [Mixtral of Experts](https://mlsanity.com/paper/2401.04088/) (2024)
- [Aligning AI With Shared Human Values](https://mlsanity.com/paper/2008.02275/) (2020)
- [FlexGen: High-Throughput Generative Inference of Large Language Models with a Single GPU](https://mlsanity.com/paper/2303.06865/) (2023)
- [DeepSpeed Inference: Enabling Efficient Inference of Transformer Models at Unprecedented Scale](https://mlsanity.com/paper/2207.00032/) (2022)
- [InfiniGen: Efficient Generative Inference of Large Language Models with Dynamic KV Cache Management](https://mlsanity.com/paper/2406.19707/) (2024)
- [Pre-gated MoE: An Algorithm-System Co-Design for Fast and Scalable Mixture-of-Expert Inference](https://mlsanity.com/paper/2308.12066/) (2023)
- [Fast Inference of Mixture-of-Experts Language Models with Offloading](https://mlsanity.com/paper/2312.17238/) (2023)
- [Fiddler: CPU-GPU Orchestration for Fast Inference of Mixture-of-Experts Models](https://mlsanity.com/paper/2402.07033/) (2024)
- [AdapMoE: Adaptive Sensitivity-based Expert Gating and Management for Efficient MoE Inference](https://mlsanity.com/paper/2408.10284/) (2024)
- [SwapMoE: Serving Off-the-shelf MoE-based Large Language Models with Tunable Memory Budget](https://mlsanity.com/paper/2308.15030/) (2023)

## Built on by (most cited first, 1 of 1)

- [Decoding the Skew: Distribution-Aware MoE Inference with Adaptive Kernel Dispatch](https://mlsanity.com/paper/2607.23099/) (2026)

## Abstract (arXiv)

Large Language Models (LLMs) have achieved impressive results across various tasks, yet their high computational demands pose deployment challenges, especially on consumer-grade hardware. Mixture of Experts (MoE) models provide an efficient solution through selective activation of parameter subsets, which reduces computation requirements. Despite this efficiency, state-of-the-art MoE models still require substantial memory beyond typical consumer GPU capacities. Traditional offloading methods that transfer model weights between CPU and GPU introduce latency, limiting inference performance. This paper presents a novel CPU-GPU collaborative inference framework that incorporates an expert caching mechanism on the GPU to reduce data transfer requirements and enable faster inference through cache hits. Computations are offloaded to CPU for efficient cache miss handling, which benefits from CPU multithreading optimizations. The evaluations of our framework demonstrate performance improvements and highlight the potential of CPU-GPU collaboration to maximize hardware utilization for single-request inference scenarios on consumer-grade systems. The implementation of our framework is available at https://github.com/elsa-lab/MoE-CPU-GPU-Collaborative-Inference.