# TF-MCL: Time-frequency Fusion and Multi-domain Cross-Loss for Self-supervised Depression Detection

arXiv: https://arxiv.org/abs/2512.13736 · HTML: https://mlsanity.com/paper/2512.13736/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 15 of its 41 references that are in the map.
- First posted on arXiv 14 Dec 2025.

## Builds on (most cited first, 15 of 15)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [A Simple Framework for Contrastive Learning of Visual Representations](https://mlsanity.com/paper/2002.05709/) (2020)
- [EEGNet: A Compact Convolutional Network for EEG-based Brain-Computer Interfaces](https://mlsanity.com/paper/1611.08024/) (2016)
- [TS2Vec: Towards Universal Representation of Time Series](https://mlsanity.com/paper/2106.10466/) (2021)
- [Time-Series Representation Learning via Temporal and Contextual Contrasting](https://mlsanity.com/paper/2106.14112/) (2021)
- [Self-Supervised Contrastive Pre-Training For Time Series via Time-Frequency Consistency](https://mlsanity.com/paper/2206.08496/) (2022)
- [Unsupervised Representation Learning for Time Series with Temporal Neighborhood Coding](https://mlsanity.com/paper/2106.00750/) (2021)
- [Unsupervised Time-Series Representation Learning with Iterative Bilinear Temporal-Spectral Fusion](https://mlsanity.com/paper/2202.04770/) (2022)
- [Decoding Natural Images from EEG for Object Recognition](https://mlsanity.com/paper/2308.13234/) (2023)
- [Subject-Aware Contrastive Learning for Biosignals](https://mlsanity.com/paper/2007.04871/) (2020)
- [What Makes Good Contrastive Learning on Small-Scale Wearable-based Tasks?](https://mlsanity.com/paper/2202.05998/) (2022)
- [MODMA dataset: a Multi-modal Open Dataset for Mental-disorder Analysis](https://mlsanity.com/paper/2002.09283/) (2020)
- [Contrast-Phys+: Unsupervised and Weakly-supervised Video-based Remote Physiological Measurement via Spatiotemporal Contrast](https://mlsanity.com/paper/2309.06924/) (2023)

## Abstract (arXiv)

In recent years, there has been a notable increase in the use of supervised detection methods of major depressive disorder (MDD) based on electroencephalogram (EEG) signals. However, the process of labeling MDD remains challenging. As a self-supervised learning method, contrastive learning could address the shortcomings of supervised learning methods, which are unduly reliant on labels in the context of MDD detection. However, existing contrastive learning methods are not specifically designed to characterize the time-frequency distribution of EEG signals, and their capacity to acquire low-semantic data representations is still inadequate for MDD detection tasks. To address the problem of contrastive learning method, we propose a time-frequency fusion and multi-domain cross-loss (TF-MCL) model for MDD detection. TF-MCL generates time-frequency hybrid representations through the use of a fusion mapping head (FMH), which efficiently remaps time-frequency domain information to the fusion domain, and thus can effectively enhance the model's capacity to synthesize time-frequency information. Moreover, by optimizing the multi-domain cross-loss function, the distribution of the representations in the time-frequency domain and the fusion domain is reconstructed, thereby improving the model's capacity to acquire fusion representations. We evaluated the performance of our model on the publicly available datasets MODMA and PRED+CT and show a significant improvement in accuracy, outperforming the existing state-of-the-art (SOTA) method by 5.87% and 9.96%, respectively.