# SSL-MedSAM2: A Semi-supervised Medical Image Segmentation Framework Powered by Few-shot Learning of SAM2

arXiv: https://arxiv.org/abs/2512.11548 · HTML: https://mlsanity.com/paper/2512.11548/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 17 of its 28 references that are in the map.
- First posted on arXiv 12 Dec 2025.

## Builds on (most cited first, 17 of 17)

- [Segment Anything](https://mlsanity.com/paper/2304.02643/) (2023)
- [SAM 2: Segment Anything in Images and Videos](https://mlsanity.com/paper/2408.00714/) (2024)
- [The Liver Tumor Segmentation Benchmark (LiTS)](https://mlsanity.com/paper/1901.04056/) (2019)
- [Semi-Supervised Semantic Segmentation with Cross-Consistency Training](https://mlsanity.com/paper/2003.09005/) (2020)
- [Medical SAM 2: Segment medical images as video via Segment Anything Model 2](https://mlsanity.com/paper/2408.00874/) (2024)
- [Shape-aware Semi-supervised 3D Semantic Segmentation for Medical Images](https://mlsanity.com/paper/2007.10732/) (2020)
- [Transformation Consistent Self-ensembling Model for Semi-supervised Medical Image Segmentation](https://mlsanity.com/paper/1903.00348/) (2019)
- [MedSAM2: Segment Anything in 3D Medical Images and Videos](https://mlsanity.com/paper/2504.03600/) (2025)
- [Learning with Limited Annotations: A Survey on Deep Semi-Supervised Learning for Medical Image Segmentation](https://mlsanity.com/paper/2207.14191/) (2022)
- [DeepAtlas: Joint Semi-Supervised Learning of Image Registration and Segmentation](https://mlsanity.com/paper/1904.08465/) (2019)
- [Dual-Consistency Semi-Supervised Learning with Uncertainty Quantification for COVID-19 Lesion Segmentation from CT Images](https://mlsanity.com/paper/2104.03225/) (2021)
- [SemiSAM: Enhancing Semi-Supervised Medical Image Segmentation via SAM-Assisted Consistency Regularization](https://mlsanity.com/paper/2312.06316/) (2023)
- [Label-Efficient Deep Learning in Medical Image Analysis: Challenges and Future Directions](https://mlsanity.com/paper/2303.12484/) (2023)
- [Cross Prompting Consistency with Segment Anything Model for Semi-supervised Medical Image Segmentation](https://mlsanity.com/paper/2407.05416/) (2024)
- [A Reliable and Interpretable Framework of Multi-view Learning for Liver Fibrosis Staging](https://mlsanity.com/paper/2306.12054/) (2023)
- [SamDSK: Combining Segment Anything Model with Domain-Specific Knowledge for Semi-Supervised Learning in Medical Image Segmentation](https://mlsanity.com/paper/2308.13759/) (2023)
- [MERIT: Multi-view evidential learning for reliable and interpretable liver fibrosis staging](https://mlsanity.com/paper/2405.02918/) (2024)

## Abstract (arXiv)

Despite the success of deep learning based models in medical image segmentation, most state-of-the-art (SOTA) methods perform fully-supervised learning, which commonly rely on large scale annotated training datasets. However, medical image annotation is highly time-consuming, hindering its clinical applications. Semi-supervised learning (SSL) has been emerged as an appealing strategy in training with limited annotations, largely reducing the labelling cost. We propose a novel SSL framework SSL-MedSAM2, which contains a training-free few-shot learning branch TFFS-MedSAM2 based on the pretrained large foundation model Segment Anything Model 2 (SAM2) for pseudo label generation, and an iterative fully-supervised learning branch FSL-nnUNet based on nnUNet for pseudo label refinement. The results on MICCAI2025 challenge CARE-LiSeg (Liver Segmentation) demonstrate an outstanding performance of SSL-MedSAM2 among other methods. The average dice scores on the test set in GED4 and T1 MRI are 0.9710 and 0.9648 respectively, and the Hausdorff distances are 20.07 and 21.97 respectively. The code is available via https://github.com/naisops/SSL-MedSAM2/tree/main.