# FreqDINO: Frequency-Guided Adaptation for Generalized Boundary-Aware Ultrasound Image Segmentation

arXiv: https://arxiv.org/abs/2512.11335 · HTML: https://mlsanity.com/paper/2512.11335/

## Key facts

- Cited by 3 papers in the map (data through 14 Oct 2026).
- Builds on 15 of its 23 references that are in the map.
- First posted on arXiv 12 Dec 2025.

## Builds on (most cited first, 15 of 15)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Segment Anything](https://mlsanity.com/paper/2304.02643/) (2023)
- [SAM 2: Segment Anything in Images and Videos](https://mlsanity.com/paper/2408.00714/) (2024)
- [DINOv3](https://mlsanity.com/paper/2508.10104/) (2025)
- [Medical SAM Adapter: Adapting Segment Anything Model for Medical Image Segmentation](https://mlsanity.com/paper/2304.12620/) (2023)
- [Segment Anything in Medical Images](https://mlsanity.com/paper/2304.12306/) (2023)
- [UNeXt: MLP-based Rapid Medical Image Segmentation Network](https://mlsanity.com/paper/2203.04967/) (2022)
- [MA-SAM: Modality-agnostic SAM Adaptation for 3D Medical Image Segmentation](https://mlsanity.com/paper/2309.08842/) (2023)
- [EMCAD: Efficient Multi-scale Convolutional Attention Decoding for Medical Image Segmentation](https://mlsanity.com/paper/2405.06880/) (2024)
- [SAM2-Adapter: Evaluating & Adapting Segment Anything 2 in Downstream Tasks: Camouflage, Shadow, Medical Image Segmentation, and More](https://mlsanity.com/paper/2408.04579/) (2024)
- [AAU-net: An Adaptive Attention U-net for Breast Lesions Segmentation in Ultrasound Images](https://mlsanity.com/paper/2204.12077/) (2022)
- [Modality-agnostic Domain Generalizable Medical Image Segmentation by Multi-Frequency in Multi-Scale Attention](https://mlsanity.com/paper/2405.06284/) (2024)
- [UltraSam: A Foundation Model for Ultrasound using Large Open-Access Segmentation Datasets](https://mlsanity.com/paper/2411.16222/) (2024)
- [MambaVesselNet++: A Hybrid CNN-Mamba Architecture for Medical Image Segmentation](https://mlsanity.com/paper/2507.19931/) (2025)
- [UniUltra: Interactive Parameter-Efficient SAM2 for Universal Ultrasound Segmentation](https://mlsanity.com/paper/2511.15771/) (2025)

## Built on by (most cited first, 3 of 3)

- [Less is More in Semantic Space: Intrinsic Decoupling via Clifford-M for Fundus Image Classification](https://mlsanity.com/paper/2603.20806/) (2026)
- [Rethinking the Adaptation of Vision Foundation Models for Efficient Cell Segmentation](https://mlsanity.com/paper/2606.21913/) (2026)
- [FreqDINO++: A Frequency-Guided Multi-Task Routing Vision Foundation Model for Universal Ultrasound Analysis](https://mlsanity.com/paper/2609.20340/) (2026)

## Abstract (arXiv)

Ultrasound image segmentation is pivotal for clinical diagnosis, yet challenged by speckle noise and imaging artifacts. Recently, DINOv3 has shown remarkable promise in medical image segmentation with its powerful representation capabilities. However, DINOv3, pre-trained on natural images, lacks sensitivity to ultrasound-specific boundary degradation. To address this limitation, we propose FreqDINO, a frequency-guided segmentation framework that enhances boundary perception and structural consistency. Specifically, we devise a Multi-scale Frequency Extraction and Alignment (MFEA) strategy to separate low-frequency structures and multi-scale high-frequency boundary details, and align them via learnable attention. We also introduce a Frequency-Guided Boundary Refinement (FGBR) module that extracts boundary prototypes from high-frequency components and refines spatial features. Furthermore, we design a Multi-task Boundary-Guided Decoder (MBGD) to ensure spatial coherence between boundary and semantic predictions. Extensive experiments demonstrate that FreqDINO surpasses state-of-the-art methods with superior achieves remarkable generalization capability. The code is at https://github.com/MingLang-FD/FreqDINO.