# Graph Deep Learning for Intracranial Aneurysm Blood Flow Simulation and Risk Assessment

arXiv: https://arxiv.org/abs/2512.09013 · HTML: https://mlsanity.com/paper/2512.09013/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Builds on 25 of its 88 references that are in the map.
- First posted on arXiv 9 Dec 2025.

## Builds on (most cited first, 25 of 25)

- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [Adam: A Method for Stochastic Optimization](https://mlsanity.com/paper/1412.6980/) (2014)
- [Masked Autoencoders Are Scalable Vision Learners](https://mlsanity.com/paper/2111.06377/) (2021)
- [Scaling Laws for Neural Language Models](https://mlsanity.com/paper/2001.08361/) (2020)
- [Inductive Representation Learning on Large Graphs](https://mlsanity.com/paper/1706.02216/) (2017)
- [Longformer: The Long-Document Transformer](https://mlsanity.com/paper/2004.05150/) (2020)
- [Training Compute-Optimal Large Language Models](https://mlsanity.com/paper/2203.15556/) (2022)
- [Big Bird: Transformers for Longer Sequences](https://mlsanity.com/paper/2007.14062/) (2020)
- [Root Mean Square Layer Normalization](https://mlsanity.com/paper/1910.07467/) (2019)
- [Relational inductive biases, deep learning, and graph networks](https://mlsanity.com/paper/1806.01261/) (2018)
- [Learning to Simulate Complex Physics with Graph Networks](https://mlsanity.com/paper/2002.09405/) (2020)
- [Learning Mesh-Based Simulation with Graph Networks](https://mlsanity.com/paper/2010.03409/) (2020)
- [Structured 3D Latents for Scalable and Versatile 3D Generation](https://mlsanity.com/paper/2412.01506/) (2024)
- [Language Modeling with Gated Convolutional Networks](https://mlsanity.com/paper/1612.08083/) (2016)
- [Accelerating Eulerian Fluid Simulation With Convolutional Networks](https://mlsanity.com/paper/1607.03597/) (2016)
- [MultiScale MeshGraphNets](https://mlsanity.com/paper/2210.00612/) (2022)
- [Transolver++: An Accurate Neural Solver for PDEs on Million-Scale Geometries](https://mlsanity.com/paper/2502.02414/) (2025)
- [IntrA: 3D Intracranial Aneurysm Dataset for Deep Learning](https://mlsanity.com/paper/2003.02920/) (2020)
- [Simulating Continuum Mechanics with Multi-Scale Graph Neural Networks](https://mlsanity.com/paper/2106.04900/) (2021)
- [Mesh Neural Networks for SE(3)-Equivariant Hemodynamics Estimation on the Artery Wall](https://mlsanity.com/paper/2212.05023/) (2022)
- [U-net architectures for fast prediction of incompressible laminar flows](https://mlsanity.com/paper/1910.13532/) (2019)
- [MeshMask: Physics-Based Simulations with Masked Graph Neural Networks](https://mlsanity.com/paper/2501.08738/) (2025)
- [Up-sampling-only and Adaptive Mesh-based GNN for Simulating Physical Systems](https://mlsanity.com/paper/2409.04740/) (2024)
- [TRELLIS-Enhanced Surface Features for Comprehensive Intracranial Aneurysm Analysis](https://mlsanity.com/paper/2509.03095/) (2025)
- [Curriculum Learning for Mesh-based simulations](https://mlsanity.com/paper/2509.13138/) (2025)

## Built on by (most cited first, 2 of 2)

- [Multi-fidelity graph-based neural networks architectures to learn Navier-Stokes solutions on non-parametrized 2D domains](https://mlsanity.com/paper/2601.02157/) (2026)
- [ONE CYLinder: A Benchmark for Graph-Based Surrogate Modeling of Unsteady Bluff-Body Flows](https://mlsanity.com/paper/2609.08947/) (2026)

## Abstract (arXiv)

Intracranial aneurysms remain a major cause of neurological morbidity and mortality worldwide, where rupture risk is tightly coupled to local hemodynamics particularly wall shear stress and oscillatory shear index. Conventional computational fluid dynamics simulations provide accurate insights but are prohibitively slow and require specialized expertise. Clinical imaging alternatives such as 4D Flow MRI offer direct in-vivo measurements, yet their spatial resolution remains insufficient to capture the fine-scale shear patterns that drive endothelial remodeling and rupture risk while being extremely impractical and expensive. We present a graph neural network surrogate model that bridges this gap by reproducing full-field hemodynamics directly from vascular geometries in less than one minute per cardiac cycle. Trained on a comprehensive dataset of high-fidelity simulations of patient-specific aneurysms, our architecture combines graph transformers with autoregressive predictions to accurately simulate blood flow, wall shear stress, and oscillatory shear index. The model generalizes across unseen patient geometries and inflow conditions without mesh-specific calibration. Beyond accelerating simulation, our framework establishes the foundation for clinically interpretable hemodynamic prediction. By enabling near real-time inference integrated with existing imaging pipelines, it allows direct comparison with hospital phase-diagram assessments and extends them with physically grounded, high-resolution flow fields. This work transforms high-fidelity simulations from an expert-only research tool into a deployable, data-driven decision support system. Our full pipeline delivers high-resolution hemodynamic predictions within minutes of patient imaging, without requiring computational specialists, marking a step-change toward real-time, bedside aneurysm analysis.