# Bridging spatial awareness and global context in medical image segmentation

arXiv: https://arxiv.org/abs/2512.06560 · HTML: https://mlsanity.com/paper/2512.06560/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 29 of its 44 references that are in the map.
- First posted on arXiv 6 Dec 2025.

## Builds on (most cited first, 29 of 29)

- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Densely Connected Convolutional Networks](https://mlsanity.com/paper/1608.06993/) (2016)
- [Fully Convolutional Networks for Semantic Segmentation](https://mlsanity.com/paper/1411.4038/) (2014)
- [Swin-Unet: Unet-like Pure Transformer for Medical Image Segmentation](https://mlsanity.com/paper/2105.05537/) (2021)
- [Multi-Scale Context Aggregation by Dilated Convolutions](https://mlsanity.com/paper/1511.07122/) (2015)
- [Dual Attention Network for Scene Segmentation](https://mlsanity.com/paper/1809.02983/) (2018)
- [UNet++: Redesigning Skip Connections to Exploit Multiscale Features in Image Segmentation](https://mlsanity.com/paper/1912.05074/) (2019)
- [Skin Lesion Analysis Toward Melanoma Detection: A Challenge at the 2017 International Symposium on Biomedical Imaging (ISBI), Hosted by the International Skin Imaging Collaboration (ISIC)](https://mlsanity.com/paper/1710.05006/) (2017)
- [U-Mamba: Enhancing Long-range Dependency for Biomedical Image Segmentation](https://mlsanity.com/paper/2401.04722/) (2024)
- [Road Extraction by Deep Residual U-Net](https://mlsanity.com/paper/1711.10684/) (2017)
- [Medical Transformer: Gated Axial-Attention for Medical Image Segmentation](https://mlsanity.com/paper/2102.10662/) (2021)
- [Attention Gated Networks: Learning to Leverage Salient Regions in Medical Images](https://mlsanity.com/paper/1808.08114/) (2018)
- [UCTransNet: Rethinking the Skip Connections in U-Net from a Channel-wise Perspective with Transformer](https://mlsanity.com/paper/2109.04335/) (2021)
- [MultiResUNet : Rethinking the U-Net Architecture for Multimodal Biomedical Image Segmentation](https://mlsanity.com/paper/1902.04049/) (2019)
- [Medical Image Segmentation Review: The success of U-Net](https://mlsanity.com/paper/2211.14830/) (2022)
- [UNeXt: MLP-based Rapid Medical Image Segmentation Network](https://mlsanity.com/paper/2203.04967/) (2022)
- [U-KAN Makes Strong Backbone for Medical Image Segmentation and Generation](https://mlsanity.com/paper/2406.02918/) (2024)
- [Fast-SCNN: Fast Semantic Segmentation Network](https://mlsanity.com/paper/1902.04502/) (2019)
- [UTNet: A Hybrid Transformer Architecture for Medical Image Segmentation](https://mlsanity.com/paper/2107.00781/) (2021)
- [Unified Focal loss: Generalising Dice and cross entropy-based losses to handle class imbalanced medical image segmentation](https://mlsanity.com/paper/2102.04525/) (2021)
- [LeViT-UNet: Make Faster Encoders with Transformer for Medical Image Segmentation](https://mlsanity.com/paper/2107.08623/) (2021)
- [CycleMix: A Holistic Strategy for Medical Image Segmentation from Scribble Supervision](https://mlsanity.com/paper/2203.01475/) (2022)
- [MALUNet: A Multi-Attention and Light-weight UNet for Skin Lesion Segmentation](https://mlsanity.com/paper/2211.01784/) (2022)
- [KiU-Net: Towards Accurate Segmentation of Biomedical Images using Over-complete Representations](https://mlsanity.com/paper/2006.04878/) (2020)
- [A Data-scalable Transformer for Medical Image Segmentation: Architecture, Model Efficiency, and Benchmark](https://mlsanity.com/paper/2203.00131/) (2022)
- [Sharp U-Net: Depthwise Convolutional Network for Biomedical Image Segmentation](https://mlsanity.com/paper/2107.12461/) (2021)
- [Adversarial Neural Networks in Medical Imaging Advancements and Challenges in Semantic Segmentation](https://mlsanity.com/paper/2410.13099/) (2024)
- [AWEU-Net: An Attention-Aware Weight Excitation U-Net for Lung Nodule Segmentation](https://mlsanity.com/paper/2110.05144/) (2021)

## Abstract (arXiv)

Medical image segmentation is a fundamental task in computer-aided diagnosis, requiring models that balance segmentation accuracy and computational efficiency. However, existing segmentation models often struggle to effectively capture local and global contextual information, leading to boundary pixel loss and segmentation errors. In this paper, we propose U-CycleMLP, a novel U-shaped encoder-decoder network designed to enhance segmentation performance while maintaining a lightweight architecture. The encoder learns multiscale contextual features using position attention weight excitation blocks, dense atrous blocks, and downsampling operations, effectively capturing both local and global contextual information. The decoder reconstructs high-resolution segmentation masks through upsampling operations, dense atrous blocks, and feature fusion mechanisms, ensuring precise boundary delineation. To further refine segmentation predictions, channel CycleMLP blocks are incorporated into the decoder along the skip connections, enhancing feature integration while maintaining linear computational complexity relative to input size. Experimental results, both quantitative and qualitative, across three benchmark datasets demonstrate the competitive performance of U-CycleMLP in comparison with state-of-the-art methods, achieving better segmentation accuracy across all datasets, capturing fine-grained anatomical structures, and demonstrating robustness across different medical imaging modalities. Ablation studies further highlight the importance of the model's core architectural components in enhancing segmentation accuracy.