# From static to adaptive: immune memory-based jailbreak detection for large language models

arXiv: https://arxiv.org/abs/2512.03356 · HTML: https://mlsanity.com/paper/2512.03356/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Placed in Jailbreaking, one of 12 directions in LLM safety and security.
- Builds on 42 of its 52 references that are in the map.
- First posted on arXiv 3 Dec 2025.

## Placed in

- LLM safety and security / [Jailbreaking](https://mlsanity.com/safety/jailbreaking/)

## Builds on (most cited first, 30 of 42)

- [GPT-4 Technical Report](https://mlsanity.com/paper/2303.08774/) (2023)
- [Training language models to follow instructions with human feedback](https://mlsanity.com/paper/2203.02155/) (2022)
- [Reflexion: Language Agents with Verbal Reinforcement Learning](https://mlsanity.com/paper/2303.11366/) (2023)
- [Universal and Transferable Adversarial Attacks on Aligned Language Models](https://mlsanity.com/paper/2307.15043/) (2023)
- [A Survey on Large Language Model based Autonomous Agents](https://mlsanity.com/paper/2308.11432/) (2023)
- [Voyager: An Open-Ended Embodied Agent with Large Language Models](https://mlsanity.com/paper/2305.16291/) (2023)
- [AutoGen: Enabling Next-Gen LLM Applications via Multi-Agent Conversation](https://mlsanity.com/paper/2308.08155/) (2023)
- [MetaGPT: Meta Programming for A Multi-Agent Collaborative Framework](https://mlsanity.com/paper/2308.00352/) (2023)
- [Jailbroken: How Does LLM Safety Training Fail?](https://mlsanity.com/paper/2307.02483/) (2023)
- [The Rise and Potential of Large Language Model Based Agents: A Survey](https://mlsanity.com/paper/2309.07864/) (2023)
- [Jailbreaking Black Box Large Language Models in Twenty Queries](https://mlsanity.com/paper/2310.08419/) (2023)
- [CAMEL: Communicative Agents for "Mind" Exploration of Large Language Model Society](https://mlsanity.com/paper/2303.17760/) (2023)
- [Llama Guard: LLM-based Input-Output Safeguard for Human-AI Conversations](https://mlsanity.com/paper/2312.06674/) (2023)
- [Baseline Defenses for Adversarial Attacks Against Aligned Language Models](https://mlsanity.com/paper/2309.00614/) (2023)
- [WildGuard: Open One-Stop Moderation Tools for Safety Risks, Jailbreaks, and Refusals of LLMs](https://mlsanity.com/paper/2406.18495/) (2024)
- [Jailbreaking Leading Safety-Aligned LLMs with Simple Adaptive Attacks](https://mlsanity.com/paper/2404.02151/) (2024)
- [SmoothLLM: Defending Large Language Models Against Jailbreaking Attacks](https://mlsanity.com/paper/2310.03684/) (2023)
- [Detecting Language Model Attacks with Perplexity](https://mlsanity.com/paper/2308.14132/) (2023)
- [Jailbreak and Guard Aligned Language Models with Only Few In-Context Demonstrations](https://mlsanity.com/paper/2310.06387/) (2023)
- [Great, Now Write an Article About That: The Crescendo Multi-Turn LLM Jailbreak Attack](https://mlsanity.com/paper/2404.01833/) (2024)
- [LLM Self Defense: By Self Examination, LLMs Know They Are Being Tricked](https://mlsanity.com/paper/2308.07308/) (2023)
- [Multilingual Jailbreak Challenges in Large Language Models](https://mlsanity.com/paper/2310.06474/) (2023)
- [JailBreakV: A Benchmark for Assessing the Robustness of MultiModal Large Language Models against Jailbreak Attacks](https://mlsanity.com/paper/2404.03027/) (2024)
- [Jailbreak Attacks and Defenses Against Large Language Models: A Survey](https://mlsanity.com/paper/2407.04295/) (2024)
- [SALAD-Bench: A Hierarchical and Comprehensive Safety Benchmark for Large Language Models](https://mlsanity.com/paper/2402.05044/) (2024)
- [Large Language Model Agent: A Survey on Methodology, Applications and Challenges](https://mlsanity.com/paper/2503.21460/) (2025)
- [AutoDAN-Turbo: A Lifelong Agent for Strategy Self-Exploration to Jailbreak LLMs](https://mlsanity.com/paper/2410.05295/) (2024)
- [AutoDefense: Multi-Agent LLM Defense against Jailbreak Attacks](https://mlsanity.com/paper/2403.04783/) (2024)
- [DrAttack: Prompt Decomposition and Reconstruction Makes Powerful LLM Jailbreakers](https://mlsanity.com/paper/2402.16914/) (2024)
- [GradSafe: Detecting Jailbreak Prompts for LLMs via Safety-Critical Gradient Analysis](https://mlsanity.com/paper/2402.13494/) (2024)

## Built on by (most cited first, 1 of 1)

- [LiSA: Lifelong Safety Adaptation via Conservative Policy Induction](https://mlsanity.com/paper/2605.14454/) (2026)

## Abstract (arXiv)

Large Language Models (LLMs) serve as the backbone of modern AI systems, yet they remain susceptible to adversarial jailbreak attacks. Consequently, robust detection of such malicious inputs is paramount for ensuring model safety. Traditional detection methods typically rely on external models trained on fixed, large-scale datasets, which often incur significant computational overhead. While recent methods shift toward leveraging internal safety signals of models to enable more lightweight and efficient detection. However, these methods remain inherently static and struggle to adapt to the evolving nature of jailbreak attacks. Drawing inspiration from the biological immune mechanism, we introduce the Immune Memory Adaptive Guard (IMAG) framework. By distilling and encoding safety patterns into a persistent, evolvable memory bank, IMAG enables adaptive generalization to emerging threats. Specifically, the framework orchestrates three synergistic components: Immune Detection, which employs retrieval for high-efficiency interception of known jailbreak attacks; Active Immunity, which performs proactive behavioral simulation to resolve ambiguous unknown queries; Memory Updating, which integrates validated attack patterns back into the memory bank. This closed-loop architecture transitions LLM defense from rigid filtering to autonomous adaptive mitigation. Extensive evaluations across five representative open-source LLMs demonstrate that our method surpasses state-of-the-art (SOTA) baselines, achieving a superior average detection accuracy of 94% across diverse and complex attack types.