# From Panel to Pixel: Zoom-In Vision-Language Pretraining from Biomedical Scientific Literature

arXiv: https://arxiv.org/abs/2512.02566 · HTML: https://mlsanity.com/paper/2512.02566/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Medical vision-language models, one of 16 directions in Multimodal LLMs / vision-language models.
- Builds on 33 of its 43 references that are in the map.
- First posted on arXiv 2 Dec 2025.

## Placed in

- Multimodal LLMs / vision-language models / [Medical vision-language models](https://mlsanity.com/mllm/medical-vision-language-models/)

## Builds on (most cited first, 30 of 33)

- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [CheXpert: A Large Chest Radiograph Dataset with Uncertainty Labels and Expert Comparison](https://mlsanity.com/paper/1901.07031/) (2019)
- [Grounded Language-Image Pre-training](https://mlsanity.com/paper/2112.03857/) (2021)
- [Kosmos-2: Grounding Multimodal Large Language Models to the World](https://mlsanity.com/paper/2306.14824/) (2023)
- [MedMNIST v2 -- A large-scale lightweight benchmark for 2D and 3D biomedical image classification](https://mlsanity.com/paper/2110.14795/) (2021)
- [FILIP: Fine-grained Interactive Language-Image Pre-Training](https://mlsanity.com/paper/2111.07783/) (2021)
- [DenseCLIP: Language-Guided Dense Prediction with Context-Aware Prompting](https://mlsanity.com/paper/2112.01518/) (2021)
- [BiomedCLIP: a multimodal biomedical foundation model pretrained from fifteen million scientific image-text pairs](https://mlsanity.com/paper/2303.00915/) (2023)
- [MedGemma Technical Report](https://mlsanity.com/paper/2507.05201/) (2025)
- [Med-Flamingo: a Multimodal Medical Few-shot Learner](https://mlsanity.com/paper/2307.15189/) (2023)
- [Long-CLIP: Unlocking the Long-Text Capability of CLIP](https://mlsanity.com/paper/2403.15378/) (2024)
- [X-CLIP: End-to-End Multi-grained Contrastive Learning for Video-Text Retrieval](https://mlsanity.com/paper/2207.07285/) (2022)
- [Improving CLIP Training with Language Rewrites](https://mlsanity.com/paper/2305.20088/) (2023)
- [PMC-CLIP: Contrastive Language-Image Pre-training using Biomedical Documents](https://mlsanity.com/paper/2303.07240/) (2023)
- [SegCLIP: Patch Aggregation with Learnable Centers for Open-Vocabulary Semantic Segmentation](https://mlsanity.com/paper/2211.14813/) (2022)
- [Alpha-CLIP: A CLIP Model Focusing on Wherever You Want](https://mlsanity.com/paper/2312.03818/) (2023)
- [CORA: Adapting CLIP for Open-Vocabulary Detection with Region Prompting and Anchor Pre-Matching](https://mlsanity.com/paper/2303.13076/) (2023)
- [Aligning Bag of Regions for Open-Vocabulary Object Detection](https://mlsanity.com/paper/2302.13996/) (2023)
- [PyramidCLIP: Hierarchical Feature Alignment for Vision-language Model Pretraining](https://mlsanity.com/paper/2204.14095/) (2022)
- [Lung and Colon Cancer Histopathological Image Dataset (LC25000)](https://mlsanity.com/paper/1912.12142/) (2019)
- [ALIP: Adaptive Language-Image Pre-training with Synthetic Caption](https://mlsanity.com/paper/2308.08428/) (2023)
- [Learning Multi-modal Representations by Watching Hundreds of Surgical Video Lectures](https://mlsanity.com/paper/2307.15220/) (2023)
- [HierVL: Learning Hierarchical Video-Language Embeddings](https://mlsanity.com/paper/2301.02311/) (2023)
- [Procedure-Aware Surgical Video-language Pretraining with Hierarchical Knowledge Augmentation](https://mlsanity.com/paper/2410.00263/) (2024)
- [CXR-LLAVA: a multimodal large language model for interpreting chest X-ray images](https://mlsanity.com/paper/2310.18341/) (2023)
- [VividMed: Vision Language Model with Versatile Visual Grounding for Medicine](https://mlsanity.com/paper/2410.12694/) (2024)
- [μ-Bench: A Vision-Language Benchmark for Microscopy Understanding](https://mlsanity.com/paper/2407.01791/) (2024)
- [Advancing Myopia To Holism: Fully Contrastive Language-Image Pre-training](https://mlsanity.com/paper/2412.00440/) (2024)
- [FG-CLIP 2: A Bilingual Fine-grained Vision-Language Alignment Model](https://mlsanity.com/paper/2510.10921/) (2025)
- [Unbiased Region-Language Alignment for Open-Vocabulary Dense Prediction](https://mlsanity.com/paper/2412.06244/) (2024)

## Abstract (arXiv)

There is a growing interest in developing strong biomedical vision-language models. A popular approach to achieve robust representations is to use web-scale scientific data. However, current biomedical vision-language pretraining typically compresses rich scientific figures and text into coarse figure-level pairs, discarding the fine-grained correspondences that clinicians actually rely on when zooming into local structures. To tackle this issue, we introduce Panel2Patch, a novel data pipeline that mines hierarchical structure from existing biomedical scientific literature, i.e., multi-panel, marker-heavy figures and their surrounding text, and converts them into multi-granular supervision. Given scientific figures and captions, Panel2Patch parses layouts, panels, and visual markers, then constructs hierarchical aligned vision-language pairs at the figure, panel, and patch levels, preserving local semantics instead of treating each figure as a single data sample. Built on this hierarchical corpus, we develop a granularity-aware pretraining strategy that unifies heterogeneous objectives from coarse didactic descriptions to fine region-focused phrases. By applying Panel2Patch to only a small set of the literature figures, we extract far more effective supervision than prior pipelines, enabling substantially better performance with less pretraining data.