# MasHeNe: A Benchmark for Head and Neck CT Mass Segmentation using Window-Enhanced Mamba with Frequency-Domain Integration

arXiv: https://arxiv.org/abs/2512.01563 · HTML: https://mlsanity.com/paper/2512.01563/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Mamba for medical image analysis, one of 10 directions in State-space sequence models (S4, Mamba).
- Builds on 18 of its 40 references that are in the map.
- First posted on arXiv 1 Dec 2025.

## Placed in

- State-space sequence models (S4, Mamba) / [Mamba for medical image analysis](https://mlsanity.com/ssm/mamba-for-medical-image-analysis/)

## Builds on (most cited first, 18 of 18)

- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Mamba: Linear-Time Sequence Modeling with Selective State Spaces](https://mlsanity.com/paper/2312.00752/) (2023)
- [SegFormer: Simple and Efficient Design for Semantic Segmentation with Transformers](https://mlsanity.com/paper/2105.15203/) (2021)
- [TransUNet: Transformers Make Strong Encoders for Medical Image Segmentation](https://mlsanity.com/paper/2102.04306/) (2021)
- [UNet++: A Nested U-Net Architecture for Medical Image Segmentation](https://mlsanity.com/paper/1807.10165/) (2018)
- [Attention U-Net: Learning Where to Look for the Pancreas](https://mlsanity.com/paper/1804.03999/) (2018)
- [UNETR: Transformers for 3D Medical Image Segmentation](https://mlsanity.com/paper/2103.10504/) (2021)
- [Swin UNETR: Swin Transformers for Semantic Segmentation of Brain Tumors in MRI Images](https://mlsanity.com/paper/2201.01266/) (2022)
- [U-Mamba: Enhancing Long-range Dependency for Biomedical Image Segmentation](https://mlsanity.com/paper/2401.04722/) (2024)
- [Deeply-Supervised Nets](https://mlsanity.com/paper/1409.5185/) (2014)
- [VM-UNet: Vision Mamba UNet for Medical Image Segmentation](https://mlsanity.com/paper/2402.02491/) (2024)
- [Recurrent Residual Convolutional Neural Network based on U-Net (R2U-Net) for Medical Image Segmentation](https://mlsanity.com/paper/1802.06955/) (2018)
- [Swin-UMamba: Mamba-based UNet with ImageNet-based pretraining](https://mlsanity.com/paper/2402.03302/) (2024)
- [Radiomics strategies for risk assessment of tumour failure in head-and-neck cancer](https://mlsanity.com/paper/1703.08516/) (2017)
- [SegRap2023: A Benchmark of Organs-at-Risk and Gross Tumor Volume Segmentation for Radiotherapy Planning of Nasopharyngeal Carcinoma](https://mlsanity.com/paper/2312.09576/) (2023)
- [Stochastic tissue window normalization of deep learning on computed tomography](https://mlsanity.com/paper/1912.00420/) (2019)
- [View it like a radiologist: Shifted windows for deep learning augmentation of CT images](https://mlsanity.com/paper/2311.14990/) (2023)

## Abstract (arXiv)

Head and neck masses are space-occupying lesions that can compress the airway and esophagus and may affect nerves and blood vessels. Available public datasets primarily focus on malignant lesions and often overlook other space-occupying conditions in this region. To address this gap, we introduce MasHeNe, an initial dataset of 3,779 contrast-enhanced CT slices that includes both tumors and cysts with pixel-level annotations. We also establish a benchmark using standard segmentation baselines and report common metrics to enable fair comparison. In addition, we propose the Windowing-Enhanced Mamba with Frequency integration (WEMF) model. WEMF applies tri-window enhancement to enrich the input appearance before feature extraction. It further uses multi-frequency attention to fuse information across skip connections within a U-shaped Mamba backbone. On MasHeNe, WEMF attains the best performance among evaluated methods, with a Dice of 70.45%, IoU of 66.89%, NSD of 72.33%, and HD95 of 5.12 mm. This model indicates stable and strong results on this challenging task. MasHeNe provides a benchmark for head-and-neck mass segmentation beyond malignancy-only datasets. The observed error patterns also suggest that this task remains challenging and requires further research. Our dataset and code are available at https://github.com/drthaodao3101/MasHeNe.git.