# Sleep Apnea Detection on a Wireless Multimodal Wearable Device Without Oxygen Flow Using a Mamba-based Deep Learning Approach

arXiv: https://arxiv.org/abs/2512.00989 · HTML: https://mlsanity.com/paper/2512.00989/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 6 of its 38 references that are in the map.
- First posted on arXiv 30 Nov 2025.

## Builds on (most cited first, 6 of 6)

- [You Only Look Once: Unified, Real-Time Object Detection](https://mlsanity.com/paper/1506.02640/) (2015)
- [Mamba: Linear-Time Sequence Modeling with Selective State Spaces](https://mlsanity.com/paper/2312.00752/) (2023)
- [Dropout as a Bayesian Approximation: Representing Model Uncertainty in Deep Learning](https://mlsanity.com/paper/1506.02142/) (2015)
- [Generalised Dice overlap as a deep learning loss function for highly unbalanced segmentations](https://mlsanity.com/paper/1707.03237/) (2017)
- [LocalMamba: Visual State Space Model with Windowed Selective Scan](https://mlsanity.com/paper/2403.09338/) (2024)
- [Mamba-based Deep Learning Approach for Sleep Staging on a Wireless Multimodal Wearable System without Electroencephalography](https://mlsanity.com/paper/2412.15947/) (2024)

## Abstract (arXiv)

Objectives: We present and evaluate a Mamba-based deep-learning model for diagnosis and event-level characterization of sleep disordered breathing based on signals from the ANNE One, a non-intrusive dual-module wireless wearable system measuring chest electrocardiography, triaxial accelerometry, chest and finger temperature, and finger phototplethysmography. Methods: We obtained concurrent PSG and wearable sensor recordings from 384 adults attending a tertiary care sleep laboratory. Respiratory events in the PSG were manually annotated in accordance with AASM guidelines. Wearable sensor and PSG recordings were automatically aligned based on the ECG signal, alignment confirmed by visual inspection, and PSG-derived respiratory event labels were used to train and evaluate a deep sequential neural network based on the Mamba architecture. Results: In 57 recordings in our test set (mean age 56, mean AHI 10.8, 43.86% female) the model-predicted AHI was highly correlated with that derived form the PSG labels (R=0.95, p=8.3e-30, men absolute error 2.83). This performance did not vary with age or sex. At a threshold of AHI>5, the model had a sensitivity of 0.96, specificity of 0.87, and kappa of 0.82, and at a threshold of AHI>15, the model had a sensitivity of 0.86, specificity of 0.98, and kappa of 0.85. At the level of 30-sec epochs, the model had a sensitivity of 0.93 and specificity of 0.95, with a kappa of 0.68 regarding whether any given epoch contained a respiratory event. Conclusions: Applied to data from the ANNE One, a Mamba-based deep learning model can accurately predict AHI and identify SDB at clinically relevant thresholds, achieves good epoch- and event-level identification of individual respiratory events, and shows promise at physiological characterization of these events including event type (central vs. other) and event duration.