# XAI-Driven Skin Disease Classification: Leveraging GANs to Augment ResNet-50 Performance

arXiv: https://arxiv.org/abs/2512.00626 · HTML: https://mlsanity.com/paper/2512.00626/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 1 of its 24 references that are in the map.
- First posted on arXiv 29 Nov 2025.

## Builds on (most cited first, 1 of 1)

- [Multi-class Skin Cancer Classification Architecture Based on Deep Convolutional Neural Network](https://mlsanity.com/paper/2303.07520/) (2023)

## Abstract (arXiv)

Accurate and timely diagnosis of multi-class skin lesions is hampered by subjective methods, inherent data imbalance in datasets like HAM10000, and the "black box" nature of Deep Learning (DL) models. This study proposes a trustworthy and highly accurate Computer-Aided Diagnosis (CAD) system to overcome these limitations. The approach utilizes Deep Convolutional Generative Adversarial Networks (DCGANs) for per class data augmentation to resolve the critical class imbalance problem. A fine-tuned ResNet-50 classifier is then trained on the augmented dataset to classify seven skin disease categories. Crucially, LIME and SHAP Explainable AI (XAI) techniques are integrated to provide transparency by confirming that predictions are based on clinically relevant features like irregular morphology. The system achieved a high overall Accuracy of 92.50 % and a Macro-AUC of 98.82 %, successfully outperforming various prior benchmarked architectures. This work successfully validates a verifiable framework that combines high performance with the essential clinical interpretability required for safe diagnostic deployment. Future research should prioritize enhancing discrimination for critical categories, such as Melanoma NOS (F1-Score is 0.8602).