# Neuroscience-Inspired Memory Replay for Continual Learning: A Comparative Study of Predictive Coding and Backpropagation-Based Strategies

arXiv: https://arxiv.org/abs/2512.00619 · HTML: https://mlsanity.com/paper/2512.00619/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 10 of its 19 references that are in the map.
- First posted on arXiv 29 Nov 2025.

## Builds on (most cited first, 10 of 10)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Adam: A Method for Stochastic Optimization](https://mlsanity.com/paper/1412.6980/) (2014)
- [Overcoming catastrophic forgetting in neural networks](https://mlsanity.com/paper/1612.00796/) (2016)
- [iCaRL: Incremental Classifier and Representation Learning](https://mlsanity.com/paper/1611.07725/) (2016)
- [Progressive Neural Networks](https://mlsanity.com/paper/1606.04671/) (2016)
- [Continual Learning with Deep Generative Replay](https://mlsanity.com/paper/1705.08690/) (2017)
- [Efficient Lifelong Learning with A-GEM](https://mlsanity.com/paper/1812.00420/) (2018)
- [Lifelong Learning with Dynamically Expandable Networks](https://mlsanity.com/paper/1708.01547/) (2017)
- [Generative replay with feedback connections as a general strategy for continual learning](https://mlsanity.com/paper/1809.10635/) (2018)
- [Predictive Coding Approximates Backprop along Arbitrary Computation Graphs](https://mlsanity.com/paper/2006.04182/) (2020)

## Abstract (arXiv)

Continual learning remains a fundamental challenge in artificial intelligence, with catastrophic forgetting posing a significant barrier to deploying neural networks in dynamic environments. Inspired by biological memory consolidation mechanisms, we propose a novel framework for generative replay that leverages predictive coding principles to mitigate forgetting. We present a comprehensive comparison between predictive coding-based and backpropagation-based generative replay strategies, evaluating their effectiveness on task retention and transfer efficiency across multiple benchmark datasets. Our experimental results demonstrate that predictive coding-based replay achieves superior retention performance (average 15.3% improvement) while maintaining competitive transfer efficiency, suggesting that biologically-inspired mechanisms can offer principled solutions to continual learning challenges. The proposed framework provides insights into the relationship between biological memory processes and artificial learning systems, opening new avenues for neuroscience-inspired AI research.