# Analysis of Invasive Breast Cancer in Mammograms Using YOLO, Explainability, and Domain Adaptation

arXiv: https://arxiv.org/abs/2512.00129 · HTML: https://mlsanity.com/paper/2512.00129/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 11 of its 44 references that are in the map.
- First posted on arXiv 28 Nov 2025.

## Builds on (most cited first, 11 of 11)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Faster R-CNN: Towards Real-Time Object Detection with Region Proposal Networks](https://mlsanity.com/paper/1506.01497/) (2015)
- [Grad-CAM: Visual Explanations from Deep Networks via Gradient-based Localization](https://mlsanity.com/paper/1610.02391/) (2016)
- [A Unified Approach to Interpreting Model Predictions](https://mlsanity.com/paper/1705.07874/) (2017)
- ["Why Should I Trust You?": Explaining the Predictions of Any Classifier](https://mlsanity.com/paper/1602.04938/) (2016)
- [You Only Look Once: Unified, Real-Time Object Detection](https://mlsanity.com/paper/1506.02640/) (2015)
- [SSD: Single Shot MultiBox Detector](https://mlsanity.com/paper/1512.02325/) (2015)
- [A Comprehensive Review of YOLO Architectures in Computer Vision: From YOLOv1 to YOLOv8 and YOLO-NAS](https://mlsanity.com/paper/2304.00501/) (2023)
- [Explainable Artificial Intelligence for Human Decision-Support System in Medical Domain](https://mlsanity.com/paper/2105.02357/) (2021)
- [Is Grad-CAM Explainable in Medical Images?](https://mlsanity.com/paper/2307.10506/) (2023)
- [D-MASTER: Mask Annealed Transformer for Unsupervised Domain Adaptation in Breast Cancer Detection from Mammograms](https://mlsanity.com/paper/2407.06585/) (2024)

## Abstract (arXiv)

Deep learning models for breast cancer detection from mammographic images have significant reliability problems when presented with Out-of-Domain (OOD) inputs such as other imaging modalities (CT, MRI, X-ray) or equipment variations, leading to unreliable detection and misdiagnosis. The current research mitigates the fundamental OOD issue through a comprehensive approach integrating ResNet50-based OOD filtering with YOLO architectures (YOLOv8, YOLOv11, YOLOv12) for accurate detection of breast cancer. Our strategy establishes an in-domain gallery via cosine similarity to rigidly reject non-mammographic inputs prior to processing, ensuring that only domain-associated images supply the detection pipeline. The OOD detection component achieves 99.77% general accuracy with immaculate 100% accuracy on OOD test sets, effectively eliminating irrelevant imaging modalities. ResNet50 was selected as the optimum backbone after 12 CNN architecture searches. The joint framework unites OOD robustness with high detection performance (mAP@0.5: 0.947) and enhanced interpretability through Grad-CAM visualizations. Experimental validation establishes that OOD filtering significantly improves system reliability by preventing false alarms on out-of-distribution inputs while maintaining higher detection accuracy on mammographic data. The present study offers a fundamental foundation for the deployment of reliable AI-based breast cancer detection systems in diverse clinical environments with inherent data heterogeneity.