# Deformation-aware Temporal Generation for Early Prediction of Alzheimers Disease

arXiv: https://arxiv.org/abs/2511.21114 · HTML: https://mlsanity.com/paper/2511.21114/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 15 of its 41 references that are in the map.
- First posted on arXiv 26 Nov 2025.

## Builds on (most cited first, 15 of 15)

- [Image-to-Image Translation with Conditional Adversarial Networks](https://mlsanity.com/paper/1611.07004/) (2016)
- [Convolutional LSTM Network: A Machine Learning Approach for Precipitation Nowcasting](https://mlsanity.com/paper/1506.04214/) (2015)
- [FlowNet: Learning Optical Flow with Convolutional Networks](https://mlsanity.com/paper/1504.06852/) (2015)
- [Super SloMo: High Quality Estimation of Multiple Intermediate Frames for Video Interpolation](https://mlsanity.com/paper/1712.00080/) (2017)
- [PredRNN: A Recurrent Neural Network for Spatiotemporal Predictive Learning](https://mlsanity.com/paper/2103.09504/) (2021)
- [Decomposing Motion and Content for Natural Video Sequence Prediction](https://mlsanity.com/paper/1706.08033/) (2017)
- [Unsupervised Learning of Disentangled Representations from Video](https://mlsanity.com/paper/1705.10915/) (2017)
- [A Review on Deep Learning Techniques for Video Prediction](https://mlsanity.com/paper/2004.05214/) (2020)
- [FLAVR: Flow-Agnostic Video Representations for Fast Frame Interpolation](https://mlsanity.com/paper/2012.08512/) (2020)
- [Dual Motion GAN for Future-Flow Embedded Video Prediction](https://mlsanity.com/paper/1708.00284/) (2017)
- [Folded Recurrent Neural Networks for Future Video Prediction](https://mlsanity.com/paper/1712.00311/) (2017)
- [Learning to synthesise the ageing brain without longitudinal data](https://mlsanity.com/paper/1912.02620/) (2019)
- [Joint Progressive and Coarse-to-fine Registration of Brain MRI via Deformation Field Integration and Non-Rigid Feature Fusion](https://mlsanity.com/paper/2109.12384/) (2021)
- [VPTR: Efficient Transformers for Video Prediction](https://mlsanity.com/paper/2203.15836/) (2022)
- [GANDALF: Generative Adversarial Networks with Discriminator-Adaptive Loss Fine-tuning for Alzheimer's Disease Diagnosis from MRI](https://mlsanity.com/paper/2008.04396/) (2020)

## Built on by (most cited first, 1 of 1)

- [Progression as Latent Drift: Generative Forecasting of Slow-Evolving Pathologies](https://mlsanity.com/paper/2607.08270/) (2026)

## Abstract (arXiv)

Alzheimer's disease (AD), a degenerative brain condition, can benefit from early prediction to slow its progression. As the disease progresses, patients typically undergo brain atrophy. Current prediction methods for Alzheimers disease largely involve analyzing morphological changes in brain images through manual feature extraction. This paper proposes a novel method, the Deformation-Aware Temporal Generative Network (DATGN), to automate the learning of morphological changes in brain images about disease progression for early prediction. Given the common occurrence of missing data in the temporal sequences of MRI images, DATGN initially interpolates incomplete sequences. Subsequently, a bidirectional temporal deformation-aware module guides the network in generating future MRI images that adhere to the disease's progression, facilitating early prediction of Alzheimer's disease. DATGN was tested for the generation of temporal sequences of future MRI images using the ADNI dataset, and the experimental results are competitive in terms of PSNR and MMSE image quality metrics. Furthermore, when DATGN-generated synthetic data was integrated into the SVM vs. CNN vs. 3DCNN-based classification methods, significant improvements were achieved from 6. 21% to 16% in AD vs. NC classification accuracy and from 7. 34% to 21. 25% in AD vs. MCI vs. NC classification accuracy. The qualitative visualization results indicate that DATGN produces MRI images consistent with the brain atrophy trend in Alzheimer's disease, enabling early disease prediction.