# Patch-Level Glioblastoma Subregion Classification with a Contrastive Learning-Based Encoder

arXiv: https://arxiv.org/abs/2511.20221 · HTML: https://mlsanity.com/paper/2511.20221/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 5 of its 12 references that are in the map.
- First posted on arXiv 25 Nov 2025.

## Builds on (most cited first, 5 of 5)

- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [DINOv2: Learning Robust Visual Features without Supervision](https://mlsanity.com/paper/2304.07193/) (2023)
- [Vision Transformers Need Registers](https://mlsanity.com/paper/2309.16588/) (2023)
- [Virchow2: Scaling Self-Supervised Mixed Magnification Models in Pathology](https://mlsanity.com/paper/2408.00738/) (2024)
- [BraTS-Path Challenge: Assessing Heterogeneous Histopathologic Brain Tumor Sub-regions](https://mlsanity.com/paper/2405.10871/) (2024)

## Abstract (arXiv)

The significant molecular and pathological heterogeneity of glioblastoma, an aggressive brain tumor, complicates diagnosis and patient stratification. While traditional histopathological assessment remains the standard, deep learning offers a promising path toward objective and automated analysis of whole slide images. For the BraTS-Path 2025 Challenge, we developed a method that fine-tunes a pre-trained Vision Transformer (ViT) encoder with a dedicated classification head on the official training dataset. Our model's performance on the online validation set, evaluated via the Synapse platform, yielded a Matthews Correlation Coefficient (MCC) of 0.7064 and an F1-score of 0.7676. On the final test set, the model achieved an MCC of 0.6509 and an F1-score of 0.5330, which secured our team second place in the BraTS-Pathology 2025 Challenge. Our results establish a solid baseline for ViT-based histopathological analysis, and future efforts will focus on bridging the performance gap observed on the unseen validation data.