# KOM: A Multi-Agent Artificial Intelligence System for Precision Management of Knee Osteoarthritis (KOA)

arXiv: https://arxiv.org/abs/2511.19798 · HTML: https://mlsanity.com/paper/2511.19798/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 8 of its 31 references that are in the map.
- First posted on arXiv 24 Nov 2025.

## Builds on (most cited first, 8 of 8)

- [A Unified Approach to Interpreting Model Predictions](https://mlsanity.com/paper/1705.07874/) (2017)
- [Large Language Models are not Fair Evaluators](https://mlsanity.com/paper/2305.17926/) (2023)
- [Almanac: Retrieval-Augmented Language Models for Clinical Medicine](https://mlsanity.com/paper/2303.01229/) (2023)
- [Significantly improving zero-shot X-ray pathology classification via fine-tuning pre-trained image-text encoders](https://mlsanity.com/paper/2212.07050/) (2022)
- [GPT-4V Cannot Generate Radiology Reports Yet](https://mlsanity.com/paper/2407.12176/) (2024)
- [Deep learning-based algorithm for assessment of knee osteoarthritis severity in radiographs matches performance of radiologists](https://mlsanity.com/paper/2207.12521/) (2022)
- [LLaVA-RadZ: Can Multimodal Large Language Models Effectively Tackle Zero-shot Radiology Recognition?](https://mlsanity.com/paper/2503.07487/) (2025)
- [Retrieval Augmented Generation Evaluation for Health Documents](https://mlsanity.com/paper/2505.04680/) (2025)

## Built on by (most cited first, 1 of 1)

- [A Discordance-Aware Multimodal Framework with Multi-Agent Clinical Reasoning](https://mlsanity.com/paper/2604.16333/) (2026)

## Abstract (arXiv)

Knee osteoarthritis (KOA) affects more than 600 million individuals globally and is associated with significant pain, functional impairment, and disability. While personalized multidisciplinary interventions have the potential to slow disease progression and enhance quality of life, they typically require substantial medical resources and expertise, making them difficult to implement in resource-limited settings. To address this challenge, we developed KOM, a multi-agent system designed to automate KOA evaluation, risk prediction, and treatment prescription. This system assists clinicians in performing essential tasks across the KOA care pathway and supports the generation of tailored management plans based on individual patient profiles, disease status, risk factors, and contraindications. In benchmark experiments, KOM demonstrated superior performance compared to several general-purpose large language models in imaging analysis and prescription generation. A randomized three-arm simulation study further revealed that collaboration between KOM and clinicians reduced total diagnostic and planning time by 38.5% and resulted in improved treatment quality compared to each approach used independently. These findings indicate that KOM could help facilitate automated KOA management and, when integrated into clinical workflows, has the potential to enhance care efficiency. The modular architecture of KOM may also offer valuable insights for developing AI-assisted management systems for other chronic conditions.