# A Novel Dual-Stream Framework for dMRI Tractography Streamline Classification with Joint dMRI and fMRI Data

arXiv: https://arxiv.org/abs/2511.18781 · HTML: https://mlsanity.com/paper/2511.18781/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 6 of its 19 references that are in the map.
- First posted on arXiv 24 Nov 2025.

## Builds on (most cited first, 6 of 6)

- [PointNet: Deep Learning on Point Sets for 3D Classification and Segmentation](https://mlsanity.com/paper/1612.00593/) (2016)
- [TractSeg - Fast and accurate white matter tract segmentation](https://mlsanity.com/paper/1805.07103/) (2018)
- [Superficial White Matter Analysis: An Efficient Point-cloud-based Deep Learning Framework with Supervised Contrastive Learning for Consistent Tractography Parcellation across Populations and dMRI Acquisitions](https://mlsanity.com/paper/2207.08975/) (2022)
- [TractCloud: Registration-free tractography parcellation with a novel local-global streamline point cloud representation](https://mlsanity.com/paper/2307.09000/) (2023)
- [Reconstructing the somatotopic organization of the corticospinal tract remains a challenge for modern tractography methods](https://mlsanity.com/paper/2306.05623/) (2023)
- [DMVFC: Deep Learning Based Functionally Consistent Tractography Fiber Clustering Using Multimodal Diffusion MRI and Functional MRI](https://mlsanity.com/paper/2510.24770/) (2025)

## Abstract (arXiv)

Streamline classification is essential to identify anatomically meaningful white matter tracts from diffusion MRI (dMRI) tractography. However, current streamline classification methods rely primarily on the geometric features of the streamline trajectory, failing to distinguish between functionally distinct fiber tracts with similar pathways. To address this, we introduce a novel dual-stream streamline classification framework that jointly analyzes dMRI and functional MRI (fMRI) data to enhance the functional coherence of tract parcellation. We design a novel network that performs streamline classification using a pretrained backbone model for full streamline trajectories, while augmenting with an auxiliary network that processes fMRI signals from fiber endpoint regions. We demonstrate our method by parcellating the corticospinal tract (CST) into its four somatotopic subdivisions. Experimental results from ablation studies and comparisons with state-of-the-art methods demonstrate our approach's superior performance.