# NeuroVascU-Net: A Unified Multi-Scale and Cross-Domain Adaptive Feature Fusion U-Net for Precise 3D Segmentation of Brain Vessels in Contrast-Enhanced T1 MRI

arXiv: https://arxiv.org/abs/2511.18422 · HTML: https://mlsanity.com/paper/2511.18422/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 13 of its 61 references that are in the map.
- First posted on arXiv 23 Nov 2025.

## Builds on (most cited first, 13 of 13)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [ECA-Net: Efficient Channel Attention for Deep Convolutional Neural Networks](https://mlsanity.com/paper/1910.03151/) (2019)
- [MONAI: An open-source framework for deep learning in healthcare](https://mlsanity.com/paper/2211.02701/) (2022)
- [Medical Transformer: Gated Axial-Attention for Medical Image Segmentation](https://mlsanity.com/paper/2102.10662/) (2021)
- [Efficient Multi-Scale 3D CNN with Fully Connected CRF for Accurate Brain Lesion Segmentation](https://mlsanity.com/paper/1603.05959/) (2016)
- [Global Filter Networks for Image Classification](https://mlsanity.com/paper/2107.00645/) (2021)
- [Learning SO(3) Equivariant Representations with Spherical CNNs](https://mlsanity.com/paper/1711.06721/) (2017)
- [Automated brain extraction of multi-sequence MRI using artificial neural networks](https://mlsanity.com/paper/1901.11341/) (2019)
- [Involution: Inverting the Inherence of Convolution for Visual Recognition](https://mlsanity.com/paper/2103.06255/) (2021)
- [DeepVesselNet: Vessel Segmentation, Centerline Prediction, and Bifurcation Detection in 3-D Angiographic Volumes](https://mlsanity.com/paper/1803.09340/) (2018)
- [Automatic Brain Tumor Segmentation using Cascaded Anisotropic Convolutional Neural Networks](https://mlsanity.com/paper/1709.00382/) (2017)
- [Automatic Cerebral Vessel Extraction in TOF-MRA Using Deep Learning](https://mlsanity.com/paper/2101.09253/) (2021)
- [CV-Attention UNet: Attention-based UNet for 3D Cerebrovascular Segmentation of Enhanced TOF-MRA Images](https://mlsanity.com/paper/2311.10224/) (2023)

## Abstract (arXiv)

Precise 3D segmentation of cerebral vasculature from T1-weighted contrast-enhanced (T1CE) MRI is crucial for safe neurosurgical planning. Manual delineation is time-consuming and prone to inter-observer variability, while current automated methods often trade accuracy for computational cost, limiting clinical use. We present NeuroVascU-Net, the first deep learning architecture specifically designed to segment cerebrovascular structures directly from clinically standard T1CE MRI in neuro-oncology patients, addressing a gap in prior work dominated by TOF-MRA-based approaches. NeuroVascU-Net builds on a dilated U-Net and integrates two specialized modules: a Multi-Scale Contextual Feature Fusion (MSC2F) module at the bottleneck and a Cross-Domain Adaptive Feature Fusion (CDA2F) module at deeper hierarchical layers. MSC2F captures both local and global information via multi-scale dilated convolutions, while CDA2F dynamically integrates domain-specific features, enhancing representation while keeping computation low. The model was trained and validated on a curated dataset of T1CE scans from 137 brain tumor biopsy patients, annotated by a board-certified functional neurosurgeon. NeuroVascU-Net achieved a Dice score of 0.8609 and precision of 0.8841, accurately segmenting both major and fine vascular structures. Notably, it requires only 12.4M parameters, significantly fewer than transformer-based models such as Swin U-NetR. This balance of accuracy and efficiency positions NeuroVascU-Net as a practical solution for computer-assisted neurosurgical planning.