# Early Lung Cancer Diagnosis from Virtual Follow-up LDCT Generation via Correlational Autoencoder and Latent Flow Matching

arXiv: https://arxiv.org/abs/2511.18185 · HTML: https://mlsanity.com/paper/2511.18185/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Placed in Medical imaging and segmentation, one of 14 directions in Diffusion models.
- Builds on 18 of its 39 references that are in the map.
- First posted on arXiv 22 Nov 2025.

## Placed in

- Diffusion models / [Medical imaging and segmentation](https://mlsanity.com/diffusion/medical-imaging-and-segmentation/)

## Builds on (most cited first, 18 of 18)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [The Unreasonable Effectiveness of Deep Features as a Perceptual Metric](https://mlsanity.com/paper/1801.03924/) (2018)
- [Diffusion Models Beat GANs on Image Synthesis](https://mlsanity.com/paper/2105.05233/) (2021)
- [Image-to-Image Translation with Conditional Adversarial Networks](https://mlsanity.com/paper/1611.07004/) (2016)
- [Flow Straight and Fast: Learning to Generate and Transfer Data with Rectified Flow](https://mlsanity.com/paper/2209.03003/) (2022)
- [BBDM: Image-to-image Translation with Brownian Bridge Diffusion Models](https://mlsanity.com/paper/2205.07680/) (2022)
- [Generating Images with Perceptual Similarity Metrics based on Deep Networks](https://mlsanity.com/paper/1602.02644/) (2016)
- [MedSegDiff-V2: Diffusion based Medical Image Segmentation with Transformer](https://mlsanity.com/paper/2301.11798/) (2023)
- [Conditional Diffusion Models for Semantic 3D Brain MRI Synthesis](https://mlsanity.com/paper/2305.18453/) (2023)
- [CoreDiff: Contextual Error-Modulated Generalized Diffusion Model for Low-Dose CT Denoising and Generalization](https://mlsanity.com/paper/2304.01814/) (2023)
- [Make-A-Volume: Leveraging Latent Diffusion Models for Cross-Modality 3D Brain MRI Synthesis](https://mlsanity.com/paper/2307.10094/) (2023)
- [Fast-DDPM: Fast Denoising Diffusion Probabilistic Models for Medical Image-to-Image Generation](https://mlsanity.com/paper/2405.14802/) (2024)
- [Diffusion Models for Counterfactual Generation and Anomaly Detection in Brain Images](https://mlsanity.com/paper/2308.02062/) (2023)
- [DisC-Diff: Disentangled Conditional Diffusion Model for Multi-Contrast MRI Super-Resolution](https://mlsanity.com/paper/2303.13933/) (2023)
- [ImageFlowNet: Forecasting Multiscale Image-Level Trajectories of Disease Progression with Irregularly-Sampled Longitudinal Medical Images](https://mlsanity.com/paper/2406.14794/) (2024)
- [Stage-by-stage Wavelet Optimization Refinement Diffusion Model for Sparse-View CT Reconstruction](https://mlsanity.com/paper/2308.15942/) (2023)
- [Correlational Neural Networks](https://mlsanity.com/paper/1504.07225/) (2015)

## Built on by (most cited first, 2 of 2)

- [MUMINS: Metadata-conditioned Uncertainty-aware Medical Image Next-state Synthesis](https://mlsanity.com/paper/2609.17169/) (2026)
- [NAMD: Virtual Follow-up Computed Tomography Synthesis via Nodule-Aligned Multimodal Diffusion Models for Early Lung Cancer Diagnosis](https://mlsanity.com/paper/2603.15932/) (2026)

## Abstract (arXiv)

Lung cancer is one of the most commonly diagnosed cancers, and early diagnosis is critical because the survival rate declines sharply once the disease progresses to advanced stages. However, achieving an early diagnosis remains challenging, particularly in distinguishing subtle early signals of malignancy from those of benign conditions. In clinical practice, a patient with a high risk may need to undergo an initial baseline and several annual follow-up examinations (e.g., CT scans) before receiving a definitive diagnosis, which can result in missing the optimal treatment. Recently, Artificial Intelligence (AI) methods have been increasingly used for early diagnosis of lung cancer, but most existing algorithms focus on radiomic features extraction from single early-stage CT scans. Inspired by recent advances in diffusion models for image generation, this paper proposes a generative method, named CorrFlowNet, which creates a virtual, one-year follow-up CT scan after the initial baseline scan. This virtual follow-up would allow for an early detection of malignant/benign nodules, reducing the need to wait for clinical follow-ups. During training, our approach employs a correlational autoencoder to encode both early baseline and follow-up CT images into a latent space that captures the dynamics of nodule progression as well as the correlations between them, followed by a flow matching algorithm on the latent space with a neural ordinary differential equation. An auxiliary classifier is used to further enhance the diagnostic accuracy. Evaluations on a real clinical dataset show our method can significantly improve downstream lung nodule risk assessment compared with existing baseline models. Moreover, its diagnostic accuracy is comparable with real clinical CT follow-ups, highlighting its potential to improve cancer diagnosis.