# Sparse Mixture-of-Experts for Multi-Channel Imaging: Are All Channel Interactions Required?

arXiv: https://arxiv.org/abs/2511.17400 · HTML: https://mlsanity.com/paper/2511.17400/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Vision mixture-of-experts, one of 12 directions in Mixture-of-experts.
- Builds on 12 of its 15 references that are in the map.
- First posted on arXiv 21 Nov 2025.

## Placed in

- Mixture-of-experts / [Vision mixture-of-experts](https://mlsanity.com/moe/vision-mixture-of-experts/)

## Builds on (most cited first, 12 of 12)

- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [Outrageously Large Neural Networks: The Sparsely-Gated Mixture-of-Experts Layer](https://mlsanity.com/paper/1701.06538/) (2017)
- [GShard: Scaling Giant Models with Conditional Computation and Automatic Sharding](https://mlsanity.com/paper/2006.16668/) (2020)
- [DeepSeekMoE: Towards Ultimate Expert Specialization in Mixture-of-Experts Language Models](https://mlsanity.com/paper/2401.06066/) (2024)
- [Scaling Vision with Sparse Mixture of Experts](https://mlsanity.com/paper/2106.05974/) (2021)
- [FastMoE: A Fast Mixture-of-Expert Training System](https://mlsanity.com/paper/2103.13262/) (2021)
- [Flex-MoE: Modeling Arbitrary Modality Combination via the Flexible Mixture-of-Experts](https://mlsanity.com/paper/2410.08245/) (2024)
- [Channel Vision Transformers: An Image Is Worth 1 x 16 x 16 Words](https://mlsanity.com/paper/2309.16108/) (2023)
- [LLaMA-MoE v2: Exploring Sparsity of LLaMA from Perspective of Mixture-of-Experts with Post-Training](https://mlsanity.com/paper/2411.15708/) (2024)
- [So2Sat LCZ42: A Benchmark Dataset for Global Local Climate Zones Classification](https://mlsanity.com/paper/1912.12171/) (2019)
- [ChAda-ViT : Channel Adaptive Attention for Joint Representation Learning of Heterogeneous Microscopy Images](https://mlsanity.com/paper/2311.15264/) (2023)
- [Enhancing Feature Diversity Boosts Channel-Adaptive Vision Transformers](https://mlsanity.com/paper/2405.16419/) (2024)

## Abstract (arXiv)

Vision Transformers (ViTs) have become the backbone of vision foundation models, yet their optimization for multi-channel domains - such as cell painting or satellite imagery - remains underexplored. A key challenge in these domains is capturing interactions between channels, as each channel carries different information. While existing works have shown efficacy by treating each channel independently during tokenization, this approach naturally introduces a major computational bottleneck in the attention block - channel-wise comparisons leads to a quadratic growth in attention, resulting in excessive FLOPs and high training cost. In this work, we shift focus from efficacy to the overlooked efficiency challenge in cross-channel attention and ask: "Is it necessary to model all channel interactions?". Inspired by the philosophy of Sparse Mixture-of-Experts (MoE), we propose MoE-ViT, a Mixture-of-Experts architecture for multi-channel images in ViTs, which treats each channel as an expert and employs a lightweight router to select only the most relevant experts per patch for attention. Proof-of-concept experiments on real-world datasets - JUMP-CP and So2Sat - demonstrate that MoE-ViT achieves substantial efficiency gains without sacrificing, and in some cases enhancing, performance, making it a practical and attractive backbone for multi-channel imaging.