# OmniScientist: Toward a Co-evolving Ecosystem of Human and AI Scientists

arXiv: https://arxiv.org/abs/2511.16931 · HTML: https://mlsanity.com/paper/2511.16931/

## Key facts

- Cited by 18 papers in the map (data through 14 Oct 2026).
- Builds on 28 of its 43 references that are in the map.
- First posted on arXiv 21 Nov 2025.

## Builds on (most cited first, 28 of 28)

- [Tree of Thoughts: Deliberate Problem Solving with Large Language Models](https://mlsanity.com/paper/2305.10601/) (2023)
- [The AI Scientist: Towards Fully Automated Open-Ended Scientific Discovery](https://mlsanity.com/paper/2408.06292/) (2024)
- [AlphaEvolve: A coding agent for scientific and algorithmic discovery](https://mlsanity.com/paper/2506.13131/) (2025)
- [Humanity's Last Exam](https://mlsanity.com/paper/2501.14249/) (2025)
- [Agent Laboratory: Using LLM Agents as Research Assistants](https://mlsanity.com/paper/2501.04227/) (2025)
- [The AI Scientist-v2: Workshop-Level Automated Scientific Discovery via Agentic Tree Search](https://mlsanity.com/paper/2504.08066/) (2025)
- [Accelerating scientific discovery with Co-Scientist](https://mlsanity.com/paper/2502.18864/) (2025)
- [Justice or Prejudice? Quantifying Biases in LLM-as-a-Judge](https://mlsanity.com/paper/2410.02736/) (2024)
- [Humans or LLMs as the Judge? A Study on Judgement Biases](https://mlsanity.com/paper/2402.10669/) (2024)
- [ResearchAgent: Iterative Research Idea Generation over Scientific Literature with Large Language Models](https://mlsanity.com/paper/2404.07738/) (2024)
- [Can large language models provide useful feedback on research papers? A large-scale empirical analysis](https://mlsanity.com/paper/2310.01783/) (2023)
- [SciMON: Scientific Inspiration Machines Optimized for Novelty](https://mlsanity.com/paper/2305.14259/) (2023)
- [CycleResearcher: Improving Automated Research via Automated Review](https://mlsanity.com/paper/2411.00816/) (2024)
- [MARG: Multi-Agent Review Generation for Scientific Papers](https://mlsanity.com/paper/2401.04259/) (2024)
- [DeepReview: Improving LLM-based Paper Review with Human-like Deep Thinking Process](https://mlsanity.com/paper/2503.08569/) (2025)
- [MOOSE-Chem: Large Language Models for Rediscovering Unseen Chemistry Scientific Hypotheses](https://mlsanity.com/paper/2410.07076/) (2024)
- [OpenReviewer: A Specialized Large Language Model for Generating Critical Scientific Paper Reviews](https://mlsanity.com/paper/2412.11948/) (2024)
- [DeepScientist: Advancing Frontier-Pushing Scientific Findings Progressively](https://mlsanity.com/paper/2509.26603/) (2025)
- [Large language models for automated scholarly paper review: A survey](https://mlsanity.com/paper/2501.10326/) (2025)
- [CRISPR-GPT for Agentic Automation of Gene-editing Experiments](https://mlsanity.com/paper/2404.18021/) (2024)
- [Automated Peer Reviewing in Paper SEA: Standardization, Evaluation, and Analysis](https://mlsanity.com/paper/2407.12857/) (2024)
- [TreeReview: A Dynamic Tree of Questions Framework for Deep and Efficient LLM-based Scientific Peer Review](https://mlsanity.com/paper/2506.07642/) (2025)
- [Accelerating science with human-aware artificial intelligence](https://mlsanity.com/paper/2306.01495/) (2023)
- [Stochastic Taylor Derivative Estimator: Efficient amortization for arbitrary differential operators](https://mlsanity.com/paper/2412.00088/) (2024)
- [ReviewRL: Towards Automated Scientific Review with RL](https://mlsanity.com/paper/2508.10308/) (2025)
- [LLMs as Meta-Reviewers' Assistants: A Case Study](https://mlsanity.com/paper/2402.15589/) (2024)
- [DataFinder: Scientific Dataset Recommendation from Natural Language Descriptions](https://mlsanity.com/paper/2305.16636/) (2023)
- [REMOR: Automated Peer Review Generation with LLM Reasoning and Multi-Objective Reinforcement Learning](https://mlsanity.com/paper/2505.11718/) (2025)

## Built on by (most cited first, 18 of 18)

- [EvoScientist: Towards Multi-Agent Evolving AI Scientists for End-to-End Scientific Discovery](https://mlsanity.com/paper/2603.08127/) (2026)
- [AutoResearchClaw: Self-Reinforcing Autonomous Research with Human-AI Collaboration](https://mlsanity.com/paper/2605.20025/) (2026)
- [AutoSOTA: An End-to-End Automated Research System for State-of-the-Art AI Model Discovery](https://mlsanity.com/paper/2604.05550/) (2026)
- [PaperOrchestra: A Multi-Agent Framework for Automated AI Research Paper Writing](https://mlsanity.com/paper/2604.05018/) (2026)
- [AutoResearch AI: Towards AI-Powered Research Automation for Scientific Discovery](https://mlsanity.com/paper/2605.23204/) (2026)
- [InnoEval: On Research Idea Evaluation as a Knowledge-Grounded, Multi-Perspective Reasoning Problem](https://mlsanity.com/paper/2602.14367/) (2026)
- [Human Cognition in Machines: A Unified Perspective of World Models](https://mlsanity.com/paper/2604.16592/) (2026)
- [NanoResearch: Co-Evolving Skills, Memory, and Policy for Personalized Research Automation](https://mlsanity.com/paper/2605.10813/) (2026)
- [Toward AI VIS Co-Scientists: A General and End-to-End Agent Harness for Solving Complex Data Visualization Tasks](https://mlsanity.com/paper/2605.21825/) (2026)
- [OmniScientist: An Omni-Modal Omni-Discipline AI Scientist](https://mlsanity.com/paper/2608.13558/) (2026)
- [Grounding LLMs in Scientific Discovery via Embodied Actions](https://mlsanity.com/paper/2602.20639/) (2026)
- [AgentEconomist: An End-to-end Agentic System Translating Economic Intuitions into Executable Computational Experiments](https://mlsanity.com/paper/2604.27725/) (2026)
- [AiraXiv: An AI-Driven Open-Access Platform for Human and AI Scientists](https://mlsanity.com/paper/2605.21481/) (2026)
- [Position: AI Agents in Scientific Teams Should Be Studied as Human-Agent Systems](https://mlsanity.com/paper/2608.14667/) (2026)
- [Paper Pilot: A Human-in-the-Loop Expert System for Evidence-Traceable Scientific Manuscript Generation in Applied Sciences](https://mlsanity.com/paper/2608.28596/) (2026)
- [InternReviewer & InternAdvocate: Objective Reward and Evaluation for Agentic Reinforcement Learning in Peer Review and Rebuttal](https://mlsanity.com/paper/2608.28612/) (2026)
- [TRIZa: Guiding Agent Evolution from Pattern Recognition to Solution Invention](https://mlsanity.com/paper/2610.04555/) (2026)
- [ST-Bench: A Spatial-Temporal Benchmark for Multi-Agent System Generation on Scientific Research Tasks](https://mlsanity.com/paper/2610.07763/) (2026)

## Abstract (arXiv)

With the rapid development of Large Language Models (LLMs), AI agents have demonstrated increasing proficiency in scientific tasks, ranging from hypothesis generation and experimental design to manuscript writing. Such agent systems are commonly referred to as "AI Scientists." However, existing AI Scientists predominantly formulate scientific discovery as a standalone search or optimization problem, overlooking the fact that scientific research is inherently a social and collaborative endeavor. Real-world science relies on a complex scientific infrastructure composed of collaborative mechanisms, contribution attribution, peer review, and structured scientific knowledge networks. Due to the lack of modeling for these critical dimensions, current systems struggle to establish a genuine research ecosystem or interact deeply with the human scientific community. To bridge this gap, we introduce OmniScientist, a framework that explicitly encodes the underlying mechanisms of human research into the AI scientific workflow. OmniScientist not only achieves end-to-end automation across data foundation, literature review, research ideation, experiment automation, scientific writing, and peer review, but also provides comprehensive infrastructural support by simulating the human scientific system, comprising: (1) a structured knowledge system built upon citation networks and conceptual correlations; (2) a collaborative research protocol (OSP), which enables seamless multi-agent collaboration and human researcher participation; and (3) an open evaluation platform (ScienceArena) based on blind pairwise user voting and Elo rankings. This infrastructure empowers agents to not only comprehend and leverage human knowledge systems but also to collaborate and co-evolve, fostering a sustainable and scalable innovation ecosystem.