# UniUltra: Interactive Parameter-Efficient SAM2 for Universal Ultrasound Segmentation

arXiv: https://arxiv.org/abs/2511.15771 · HTML: https://mlsanity.com/paper/2511.15771/

## Key facts

- Cited by 5 papers in the map (data through 14 Oct 2026).
- Builds on 34 of its 62 references that are in the map.
- First posted on arXiv 19 Nov 2025.

## Builds on (most cited first, 30 of 34)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [LoRA: Low-Rank Adaptation of Large Language Models](https://mlsanity.com/paper/2106.09685/) (2021)
- [Distilling the Knowledge in a Neural Network](https://mlsanity.com/paper/1503.02531/) (2015)
- [Segment Anything](https://mlsanity.com/paper/2304.02643/) (2023)
- [Gaussian Error Linear Units (GELUs)](https://mlsanity.com/paper/1606.08415/) (2016)
- [SAM 2: Segment Anything in Images and Videos](https://mlsanity.com/paper/2408.00714/) (2024)
- [Visual Prompt Tuning](https://mlsanity.com/paper/2203.12119/) (2022)
- [Segment Everything Everywhere All at Once](https://mlsanity.com/paper/2304.06718/) (2023)
- [Medical SAM Adapter: Adapting Segment Anything Model for Medical Image Segmentation](https://mlsanity.com/paper/2304.12620/) (2023)
- [Segment Anything in High Quality](https://mlsanity.com/paper/2306.01567/) (2023)
- [Faster Segment Anything: Towards Lightweight SAM for Mobile Applications](https://mlsanity.com/paper/2306.14289/) (2023)
- [Hiera: A Hierarchical Vision Transformer without the Bells-and-Whistles](https://mlsanity.com/paper/2306.00989/) (2023)
- [Customized Segment Anything Model for Medical Image Segmentation](https://mlsanity.com/paper/2304.13785/) (2023)
- [TinyViT: Fast Pretraining Distillation for Small Vision Transformers](https://mlsanity.com/paper/2207.10666/) (2022)
- [EfficientSAM: Leveraged Masked Image Pretraining for Efficient Segment Anything](https://mlsanity.com/paper/2312.00863/) (2023)
- [MA-SAM: Modality-agnostic SAM Adaptation for 3D Medical Image Segmentation](https://mlsanity.com/paper/2309.08842/) (2023)
- [E^2VPT: An Effective and Efficient Approach for Visual Prompt Tuning](https://mlsanity.com/paper/2307.13770/) (2023)
- [Convolution Meets LoRA: Parameter Efficient Finetuning for Segment Anything Model](https://mlsanity.com/paper/2401.17868/) (2024)
- [EMCAD: Efficient Multi-scale Convolutional Attention Decoding for Medical Image Segmentation](https://mlsanity.com/paper/2405.06880/) (2024)
- [SAM2-Adapter: Evaluating & Adapting Segment Anything 2 in Downstream Tasks: Camouflage, Shadow, Medical Image Segmentation, and More](https://mlsanity.com/paper/2408.04579/) (2024)
- [AAU-net: An Adaptive Attention U-net for Breast Lesions Segmentation in Ultrasound Images](https://mlsanity.com/paper/2204.12077/) (2022)
- [Beyond Adapting SAM: Towards End-to-End Ultrasound Image Segmentation via Auto Prompting](https://mlsanity.com/paper/2309.06824/) (2023)
- [Segment Anything Model for Medical Images?](https://mlsanity.com/paper/2304.14660/) (2023)
- [TinySAM: Pushing the Envelope for Efficient Segment Anything Model](https://mlsanity.com/paper/2312.13789/) (2023)
- [Modality-agnostic Domain Generalizable Medical Image Segmentation by Multi-Frequency in Multi-Scale Attention](https://mlsanity.com/paper/2405.06284/) (2024)
- [FoodSAM: Any Food Segmentation](https://mlsanity.com/paper/2308.05938/) (2023)
- [RepViT-SAM: Towards Real-Time Segmenting Anything](https://mlsanity.com/paper/2312.05760/) (2023)
- [Black-box Targeted Adversarial Attack on Segment Anything (SAM)](https://mlsanity.com/paper/2310.10010/) (2023)
- [CC-SAM: SAM with Cross-feature Attention and Context for Ultrasound Image Segmentation](https://mlsanity.com/paper/2408.00181/) (2024)
- [De-LightSAM: Modality-Decoupled Lightweight SAM for Generalizable Medical Segmentation](https://mlsanity.com/paper/2407.14153/) (2024)

## Built on by (most cited first, 5 of 5)

- [FreqDINO: Frequency-Guided Adaptation for Generalized Boundary-Aware Ultrasound Image Segmentation](https://mlsanity.com/paper/2512.11335/) (2025)
- [Cesarean Scar Defect Segmentation in Transvaginal Ultrasound Images: a Dataset and Benchmark](https://mlsanity.com/paper/2605.26774/) (2026)
- [Rethinking the Adaptation of Vision Foundation Models for Efficient Cell Segmentation](https://mlsanity.com/paper/2606.21913/) (2026)
- [An Edge-aware Prompt-enhanced SAM for Ultrasound Image Segmentation](https://mlsanity.com/paper/2607.07240/) (2026)
- [Lean-SAM2: Target-Anchored Memory and Encoder Acceleration for SAM2](https://mlsanity.com/paper/2607.19811/) (2026)

## Abstract (arXiv)

The Segment Anything Model 2 (SAM2) demonstrates remarkable universal segmentation capabilities on natural images. However, its performance on ultrasound images is significantly degraded due to domain disparities. This limitation raises two critical challenges: how to efficiently adapt SAM2 to ultrasound imaging while maintaining parameter efficiency, and how to deploy the adapted model effectively in resource-constrained clinical environments. To address these issues, we propose UniUltra for universal ultrasound segmentation. Specifically, we first introduce a novel context-edge hybrid adapter (CH-Adapter) that enhances fine-grained perception across diverse ultrasound imaging modalities while achieving parameter-efficient fine-tuning. To further improve clinical applicability, we develop a deep-supervised knowledge distillation (DSKD) technique that transfers knowledge from the large image encoder of the fine-tuned SAM2 to a super lightweight encoder, substantially reducing computational requirements without compromising performance. Extensive experiments demonstrate that UniUltra outperforms state-of-the-arts with superior generalization capabilities. Notably, our framework achieves competitive performance using only 8.91% of SAM2's parameters during fine-tuning, and the final compressed model reduces the parameter count by 94.08% compared to the original SAM2, making it highly suitable for practical clinical deployment. The source code is available at https://github.com/xq141839/UniUltra.