# Tissue Aware Nuclei Detection and Classification Model for Histopathology Images

arXiv: https://arxiv.org/abs/2511.13615 · HTML: https://mlsanity.com/paper/2511.13615/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 12 of its 19 references that are in the map.
- First posted on arXiv 17 Nov 2025.

## Builds on (most cited first, 12 of 12)

- [DINOv2: Learning Robust Visual Features without Supervision](https://mlsanity.com/paper/2304.07193/) (2023)
- [Emerging Properties in Self-Supervised Vision Transformers](https://mlsanity.com/paper/2104.14294/) (2021)
- [DINOv3](https://mlsanity.com/paper/2508.10104/) (2025)
- [CenterNet: Keypoint Triplets for Object Detection](https://mlsanity.com/paper/1904.08189/) (2019)
- [HoVer-Net: Simultaneous Segmentation and Classification of Nuclei in Multi-Tissue Histology Images](https://mlsanity.com/paper/1812.06499/) (2018)
- [Virchow2: Scaling Self-Supervised Mixed Magnification Models in Pathology](https://mlsanity.com/paper/2408.00738/) (2024)
- [CoNIC Challenge: Pushing the Frontiers of Nuclear Detection, Segmentation, Classification and Counting](https://mlsanity.com/paper/2303.06274/) (2023)
- [Domain Generalization in Computational Pathology: Survey and Guidelines](https://mlsanity.com/paper/2310.19656/) (2023)
- [Nuclei Segmentation with Point Annotations from Pathology Images via Self-Supervised Learning and Co-Training](https://mlsanity.com/paper/2202.08195/) (2022)
- [Weakly supervised segmentation with point annotations for histopathology images via contrast-based variational model](https://mlsanity.com/paper/2304.03572/) (2023)
- [On generalisability of segment anything model for nuclear instance segmentation in histology images](https://mlsanity.com/paper/2401.14248/) (2024)
- [Co-Seg++: Mutual Prompt-Guided Collaborative Learning for Versatile Medical Segmentation](https://mlsanity.com/paper/2506.17159/) (2025)

## Built on by (most cited first, 1 of 1)

- [Dino-NestedUNet: Unlocking Foundation Vision Encoders for Pathology Tumor Bulk Segmentation via Dense Decoding](https://mlsanity.com/paper/2605.00894/) (2026)

## Abstract (arXiv)

Accurate nuclei detection and classification are fundamental to computational pathology, yet existing approaches are hindered by reliance on detailed expert annotations and insufficient use of tissue context. We present Tissue-Aware Nuclei Detection (TAND), a novel framework achieving joint nuclei detection and classification using point-level supervision enhanced by tissue mask conditioning. TAND couples a ConvNeXt-based encoder-decoder with a frozen Virchow-2 tissue segmentation branch, where semantic tissue probabilities selectively modulate the classification stream through a novel multi-scale Spatial Feature-wise Linear Modulation (Spatial-FiLM). On the PUMA benchmark, TAND achieves state-of-the-art performance, surpassing both tissue-agnostic baselines and mask-supervised methods. Notably, our approach demonstrates remarkable improvements in tissue-dependent cell types such as epithelium, endothelium, and stroma. To the best of our knowledge, this is the first method to condition per-cell classification on learned tissue masks, offering a practical pathway to reduce annotation burden.